Background: In unresectable metastatic rectal cancers, surgery of primary tumor remains highly debated. Pelvic Chemoradiotherapy (CRT) could allow sufficient local control in order to avoid major and sometimes mutilating surgery. Dose escalated CRT increase control. The aim this study was evaluate the feasibility tolerance a with radiation dose escalation using intensity modulated radiotherapy ...

The aim of this work was to quantify the ability to predict intrafraction diaphragm motion from an external respiration signal during a course of radiotherapy. The data obtained included diaphragm motion traces from 63 fluoroscopic lung procedures for 5 patients, acquired simultaneously with respiratory motion signals (an infrared camera-based system was used to track abdominal wall motion). Du...

The prediction as well as the gating of respiratory motion have received much attention over the last two decades for reducing the targeting error of the radiation treatment beam due to respiratory motion. In this article, we present a real-time algorithm for predicting respiratory motion in 3D space and realizing a gating function without pre-specifying a particular phase of the patient's brea...

Dosimetric consequences of positional shifts were studied using frameless Brainlab ExacTrac X-ray system for hypofractionated (3 or 5 fractions) intracranial stereo-tactic radiotherapy (SRT). SRT treatments of 17 patients with metastatic intracranial tumors using the stereotactic system were retrospectively investigated. The treatments were simulated in a treatment planning system by modifying ...

PURPOSE To test a prone position against the international-standard supine position in women undergoing whole-breast-radiotherapy (WBRT) after wide-local-excision (WLE) of early breast cancer (BC) in terms of feasibility, set-up errors, and respiratory motion. METHODS Following WLE of BC with insertion of tumour-bed clips, patients underwent 4D-CT for WBRT-planning in supine and prone positio...

The aim of this study was to investigate the impact of multileaf collimator width (MLC-W) on intraprostatic dose painting plans for prostate cancer.Prostate cancer maps based on the histopathological findings were superimposed onto simulation CT images. Clinical target volume (CTV) 1 was defined as the prostate and the base of the seminal vesicles, and CTV2 was defined as the dominant intrapros...

The impact of the treatment couch on a radiotherapy plan is rarely fully assessed during the treatment planning process. Incorporating a couch model into the treatment planning system (TPS) enables the planner to avoid or dosimetrically evaluate beam-couch intersections. In this work, we demonstrate how existing TPS tools can be used to establish this capability and assess the accuracy and effe...

BACKGROUND The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively. METHODS The Prospective Investigation of Pulmonary Embolism Diagnosis II trial was a prospective, multicenter investigation of the accuracy of multidetector CTA alone and combined with venous-phase imaging (CTA-CTV) for the diagnos...

PURPOSE The purpose of this case series is to describe the treatment and outcomes of a cohort of patients with inoperable early-stage endometrioid endometrial cancer with 3D image-guided high-dose-rate (HDR) intracavitary brachytherapy. MATERIALS AND METHODS A review was performed of patients with early-stage endometrial cancer who underwent primary radiation treatment between 2010 and 2016. ...

PURPOSE To evaluate a new calculation model estimating the equivalent dose at 2 Gy (EQD2) taking into account dose gradient in high dose rate interstitial brachytherapy (HDRIB). MATERIAL AND METHODS Forty dose-volume histograms (DVHs) of breast (20 pts) and prostate (20 pts) cancer dose distributions were reviewed. Physical prescribed doses (PPD) were 34 Gy (10f/5d) and 18 Gy (6f/2d) for brea...