نتایج جستجو برای: cll blood cancer

تعداد نتایج: 1557686  

2017
Kemal Catakovic Franz Josef Gassner Christoph Ratswohl Nadja Zaborsky Stefan Rebhandl Maria Schubert Markus Steiner Julia Christine Gutjahr Lisa Pleyer Alexander Egle Tanja Nicole Hartmann Richard Greil Roland Geisberger

While research on T cell exhaustion in context of cancer particularly focuses on CD8+ cytotoxic T cells, the role of inhibitory receptors on CD4+ T-helper cells have remained largely unexplored. TIGIT is a recently identified inhibitory receptor on T cells and natural killer (NK) cells. In this study, we examined TIGIT expression on T cell subsets from CLL patients. While we did not observe any...

2015
Ewelina Grywalska Jacek Roliński Marcin Pasiarski Izabela Korona-Glowniak Maciej Maj Agata Surdacka Agnieszka Grafka Agnieszka Stelmach-Gołdyś Michał Zgurski Stanisław Góźdź Anna Malm Piotr Grabarczyk Elżbieta Starosławska Joseph S Pagano

Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects more than 90% of the world population. The potential involvement of EBV in the clinical course of chronic lymphocytic leukemia (CLL) remains unexplained. The aim of this study was to determine whether EBV-DNA load in the peripheral blood mononuclear cells (PBMCs) of CLL patients may influence heterogeneity in the course of the ...

2017
Shrimanjunath Sankanagoudar Govind Singh Manaranjan Mahapatra Lalit Kumar Nimai Chand Chandra

Background: This study was performed to investigate any association between cellular cholesterol homeostasis and chronic lymphocytic leukemia (CLL). CLL is characterized primarily by an abnormal accumulation of neoplastic B cells in the blood, bone marrow, lymph nodes and spleen. Methods: Men aged >50 years participated in this study. Enzyme-based plasma lipid profile estimations, peripheral bl...

2009
Antonina V. Kurtova Kumudha Balakrishnan Rong Chen Wei Ding Susanne Schnabl Maite P. Quiroga Mariela Sivina William G. Wierda Zeev Estrov Michael J. Keating Medhat Shehata Ulrich Jäger Varsha Gandhi Neil E. Kay William Plunkett Jan A. Burger

Marrow stromal cells (MSCs) provide important survival and drug resistance signals to chronic lymphocytic leukemia (CLL) cells, but current models to analyze CLL–MSC interactions are heterogeneous. Therefore, we tested different human and murine MSC lines and primary human MSCs for their ability to protect CLL cells from spontaneous and druginduced apoptosis. Our results show that both human an...

2018
Jinghua Wang Siyu Chen Wei Xiao Wende Li Liang Wang Shuo Yang Weida Wang Liping Xu Shuangye Liao Wenjian Liu Yang Wang Nawei Liu Jianeng Zhang Xiaojun Xia Tiebang Kang Gong Chen Xiuyu Cai Han Yang Xing Zhang Yue Lu Penghui Zhou

BACKGROUND Acute myeloid leukemia (AML) is one of the most common types of adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority of patients eventually relapse and succumb to the disease. Thus, the development of novel therapeutics for AML is urgently needed. Human C-type lectin-like molecule-1 (CLL-1) is a type II transmembrane gl...

2015
Ana-Carolina Martinez-Torres Claire Quiney Tarik Attout Heloïse Boullet Linda Herbi Laura Vela Sandrine Barbier Danielle Chateau Elise Chapiro Florence Nguyen-Khac Frédéric Davi Magali Le Garff-Tavernier Roba Moumné Marika Sarfati Philippe Karoyan Hélène Merle-Béral Pierre Launay Santos A. Susin

BACKGROUND Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system. Despite intense research efforts, drug resistance remains a major cause of treatment failure in CLL, particularly in patients with dysfunctional TP53. The objective of our work was to ...

2016
Nikos Papakonstantinou Stavroula Ntoufa Elisavet Chartomatsidou Konstantia Kotta Andreas Agathangelidis Lefki Giassafaki Tzeni Karamanli Panagiota Bele Theodoros Moysiadis Panagiotis Baliakas Lesley Ann Sutton Niki Stavroyianni Achilles Anagnostopoulos Antonios M. Makris Paolo Ghia Richard Rosenquist Kostas Stamatopoulos

The histone methyltransferase EZH2 induces gene repression through trimethylation of histone H3 at lysine 27 (H3K27me3). EZH2 overexpression has been reported in many types of cancer and associated with poor prognosis. Here we investigated the expression and functionality of EZH2 in chronic lymphocytic leukemia (CLL). Aggressive cases with unmutated IGHV genes (U-CLL) displayed significantly hi...

Journal: :Social Science Research Network 2021

Background: The most common B-cell cancers, chronic lymphocytic leukemia/lymphoma (CLL), follicular and diffuse large (FL, DLBCL) lymphomas, have distinct clinical courses, yet overlapping “cell-of-origin”. Dynamic changes to the epigenome are essential regulators of differentiation. Therefore, we reasoned that these cancers may be driven by shared mechanisms disruption in transcriptional circu...

Journal: :Blood 2011
Yair Herishanu Patricia Pérez-Galán Delong Liu Angélique Biancotto Stefania Pittaluga Berengere Vire Federica Gibellini Ndegwa Njuguna Elinor Lee Lawrence Stennett Nalini Raghavachari Poching Liu J Philip McCoy Mark Raffeld Maryalice Stetler-Stevenson Constance Yuan Richard Sherry Diane C Arthur Irina Maric Therese White Gerald E Marti Peter Munson Wyndham H Wilson Adrian Wiestner

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes, involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes (LN). A role of the tissue microenvironment in the pathogenesis of CLL is hypothesized based on in vitro observations, but its contribution in vivo remains ill-defined. To elucidate the effects of tumor-host interactions in vivo,...

2004
Freda K. Stevenson

The finding that chronic lymphocytic leukemia (CLL) consists of 2 clinical subsets, distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable region (V) genes, has clearly linked prognosis to biology. Antigen encounter by the cell of origin is indicated in both subsets by selective but distinct expression of V genes, with evidence for continuing stimulation after t...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید