Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides....

Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergenc...

It is known that the clock-period can be shorter than the maximum of signal-delays between registers if the clock arrival time to each register is properly scheduled. The algorithm to design an optimal clock-schedule was given. In this paper, we propose a clock-tree routing algorithm that realizes a given clock-schedule using the Elmore-delay model. Following the deferred-merge-embedding (DME) ...

We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning approximately 100,000 bp of DNA from which transcript classes of 7.5 and approximately 10 kb arise. Clock encodes a novel member of the bHLH-PAS family of transcription factors. In the Clock mutant allele, an A-->T nucleotide transversion in a splice donor site cau...

Objective: Mini-mental state examination, a nonspecific measure of global cognitive function, and the clock drawing test, a very concise and specific measure of cognitive function, are among the most widely used screening tests for cognitive dysfunction. The present research aimed to examine the correspondence between MMSE and CDT scores. Methods: A total of 70 older adults (mean(SD) age=69.70...

This paper presents the design of Wren, a new geo-replicated key-value store that achieves Transactional Causal Consistency. Wren leverages two design choices to achieve higher performance and better scalability than existing systems. First, Wren uses hybrid logical physical/clocks to timestamp data items. Hybrid clocks allow Wren to achieve low response times, by avoiding the latencies that ex...

Time synchronization is important for any distributed system. In particular, wireless sensor networks make extensive use of synchronized time in many contexts (e.g. for data fusion, TDMA schedules, synchronized sleep periods, etc.). Existing time synchronization methods were not designed with wireless sensor networks in mind, and need to be extended or redesigned. Our solution centers around th...