نتایج جستجو برای: closed in vitro dissolution test method

تعداد نتایج: 17333692  

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017
Justine Thiry Miranda G M Kok Laurence Collard Antoine Frère Fabrice Krier Marianne Fillet Brigitte Evrard

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three for...

2017
Ivelisse Colón Taryn Ryan Joseph Medendorp

Dissolution testing measures the rate of drug substance release into solution, impacting the extent of drug absorption. Drug manufacturers and regulatory agencies use dissolution testing to identify drug products that do not meet the desired clinical performance. Formulation composition and manufacturing processes can impact the material attributes of a drug product, which directly affect the d...

2015
Divya Suares Arti Hiray

The objective of this research work was to mask the intense bitter taste of fexofenadine hydrochloride using weak cation exchange resins and to formulate orodispersible tablet of taste masked drug-resin complex. Five resins indion 204, indion 234, indion 414, kyron T-114 and kyron T-314 were used. Depending on maximum drug loading capacity of resins indion 234 and kyron T-314 were finalized for...

2016
Vítor Todeschini Maximiliano S. Sangoi Gustavo K. Goelzer Jaison C. Machado Clésio S. Paim Bibiana V. Araujo Nadia M. Volpato

The present study describes the development and validation of a dissolution method for delapril (DEL) and manidipine (MAN) combination tablets, using a simulated absorption profile based on in vivo data for MAN. The suitable in vitro dissolution profile for this formulation was obtained using 900 mL of citrate buffer pH 3.2 at 37 °C±0.5 °C as dissolution medium and USP apparatus 2 (paddle) at 7...

Journal: :iranian journal of pharmaceutical sciences 0
supriya patil research group department of pharmaceutics and quality assurance, shree santkrupa college of pharmacy, ghogaon, karad 415111 ms, (india) vinit patil department of pharmaceutical technology, bharati vidyapeeth college of pharmacy kolhapur, ms, india amol shete research group department of pharmaceutics and quality assurance, shree santkrupa college of pharmacy, ghogaon, karad 415111 ms, (india), rajendra doijad research group department of pharmaceutics and quality assurance, shree santkrupa college of pharmacy, ghogaon, karad 415111 ms, (india),

the objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (sedds) in order to enhance the dissolution rate of poorly soluble irbesartan (ibs) by sedds. pseudoternary phase diagrams were constructed to identify the self emulsifying region....

Journal: :iranian journal of applied animal science 2013
k. ray b.b. ghosh

this study aimed at determining the physico-morphological attributes, in vitrofertilityand their interrelationships in semen of sahiwal bulls. semen samples werecollected weekly for 6 weeks from ten mature sahiwal bulls divided randomly into 5 groups. the mean (±sem) of ejaculate volume (ml), mass activity (score 0-5), progressive sperm motility (%), sperm concentration (106/ml), live sperm (%)...

Journal: :iranian journal of pharmaceutical sciences 0
arash hanifi department of materials science, isfahan university of technology, isfahan, iran mohammad hossein fathi department of materials science, isfahan university of technology, isfahan, iran

the bone mineral consists of tiny hydroxyapatite (ha) crystals in the nanoregime. nanostructured ha is also expected to have better bioactivity than coarser crystals. this paper reports on the in vitro evaluation of bone like ha nanopowders. the prepared ha nanopowder was characterized for its phase purity, chemical homogeneity and bioactivity. fourier transform infrared (ft-ir) spectroscopy wa...

Journal: :Dalton transactions 2016
Eranda Wanigasekara John W Freiderich Xiao-Guang Sun Roberta A Meisner Huimin Luo Lætitia H Delmau Sheng Dai Bruce A Moyer

A closed cycle is demonstrated for the tandem dissolution and electroreduction of UO3 to UO2 with regeneration of the acidic ionic liquid. The dissolution is achieved by use of the acidic ionic liquid [DMAH][NTf2] in [EMIM][NTf2] serving as the diluent. A sequential dissolution, electroreduction, and regeneration cycle is presented.

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