Cluster headache (CH) is one of the most severe types of headache, characterized by periods of recurrent attacks of sudden and intense pain, localized in the orbital or temporal region, and associated with ipsilateral autonomic symptoms and signs. The mean age of onset of CH is in the late third decade. Only few cases of childhood-onset (<14 years) CH have been reported in the literature. In th...

Occipital nerve stimulation may be effective for primary headache disorders. Four studies, including two double-blind show, stimulation-controlled studies that were performed for chronic migraine showed evidence of benefit. A separate study suggested a benefit for combined supraorbital and greater occipital nerve stimulation. Anecdotal evidence suggests benefit in hemicrania continua. In chroni...

The short-lasting primary headache syndromes may be conveniently divided into those exhibiting marked autonomic activation and those without autonomic activation. The former group comprise chronic and episodic paroxysmal hemicrania, short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT syndrome) and cluster headache. These headache syndromes are compared ...

OBJECTIVE The main object of this pilot study was to investigate the safety of administering onabotulinumtoxinA (BTA) towards the sphenopalatine ganglion (SPG) in intractable chronic cluster headache. Efficacy data were also collected to provide indication on whether future placebo-controlled studies should be performed. METHOD In a prospective, open-label, uncontrolled study, we performed a ...

BACKGROUND Suboccipital steroid injections can be used for preventive treatment of cluster headache but few data are available for the efficacy of this approach in clinical trials. We aimed to assess efficacy and safety of repeated suboccipital injections with cortivazol compared with placebo as add-on therapy in patients having frequent daily attacks. METHODS In our randomised, double-blind,...