BACKGROUND The efficacy of preemptive therapy against cytomegalovirus (CMV) infection remains unknown in treatment-naïve patients with advanced HIV-1 infection in the HAART era. METHODS The subjects of this single-center observation study were 126 treatment-naïve HIV-1 infected patients with positive CMV viremia between January 1, 2000 and December 31, 2006. Inclusion criteria were age more t...

Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence and burden of congenital CMV infection are not well defined in China.Cohort of newborns from 5 birthing hospitals in 2 counties of Shandong Province, China, were enrolled from March 2011 to August 2013. Dried blood spots (DBS) ...

Background Infection with cytomegalovirus (CMV) during pregnancy may lead to congenital disease. Very little is known about the seroepidemiology of CMV infection in pregnant women in Mexico. We sought to determine the seroprevalence and correlates of CMV infection in pregnant women in Aguascalientes City, Mexico. Methods Through a cross-sectional study design, 289 pregnant women were examined...

cucumber mosaic virus (cmv) is one of widely-spread viruses of plants with the broadest host range encompassing over 1200 species. one major limiting factor for detection of the virus is unavailability of the virus-specific antibodies especially in developing countries. recombinant dna technology facilitates antibody preparation without requiring special equipment. in this study, coat protein (...

Cytomegalovirus (CMV) is a β-herpesvirus able to replicate in fibroblasts, endothelial cells and monocytes [1]. CMV infection is usually asymptomatic, but causes a mononucleosis-like illness in some individuals. CMV disease can manifest as a syndrome or as an acute infection of an organ or tissue. CMV syndrome is characterized by fever, leukopenia, hepato-spleno‐ megaly, myalgias and occasional...

Complement provides a key immunologic defense against invading pathogens; thus, a clear understanding of the interactions between cytomegalovirus (CMV) and complement may permit the development of strategies to enhance CMV neutralization. In the presence of specific anti-CMV antibodies, complement enhanced the neutralizing ability of serum by 2- to 3-fold. However, in the absence of specific an...

Strategies for preventing posttransfusion CMV infections include testing for CMV antibodies, CMV DNA, and/or WBC reduction of blood components. 1,2 Early studies with molecular methods produced conflicting results. Nevertheless, recent investigations show that improved CMV PCR assays do not necessarily increase detection of CMV DNA in healthy CMV-seronegative blood donors. 3,4 We confirm these ...