Two bimetallic assemblies K[Cu(cyclam)][Fe(CN)6] 4H2O 1 and [Cu(L)][Cu(L )][Fe(CN)6] 6.5H2O 2 (cyclam = 1,4,8,11-tetraazacyclotetradecane; L = N,N -bis(2-pyridylmethylene)-1,3-propanediamine and L = N-2-pyridylmethylene-1,3-propanediamine) have been prepared from the reaction of [Fe(CN)6] 3 and the precursors [Cu(cyclam)] and [Cu(L)] , respectively, and their structure and magnetic properties s...

Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506. How the two structurally distinct immunophilin-drug complexes bind the same target has remained unknown. We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-A resolution. The Cy...

PURPOSE Retinoblastoma, a childhood cancer of the retina, is caused by inactivation of the tumor suppressor gene retinoblastoma (RB). Cotylenin A (CN-A), a novel fusicoccane-diterpene glycoside, accelerates the differentiation of several types of myeloid cell lines and is a candidate for a new type of anticancer therapeutic agent with this effect. However, whether CN-A has the same effect on re...

Camptothecin (CN) is active against several experimental tumors and has also been studied clinically. We report here the effect of CN on LI210 cells and asynchronous and synchronous DON cells in culture. CN was toxic both to LI210 cells (0.06 ¿ig/ml,2-hr exposure) and DON cells (0.15 Mg/ml, 1-hr exposure), and it inhibited DNA and RNA synthesis more than it inhibited protein synthesis. CN was ...

OBJECTIVE The aim of this study was to evaluate the effect of cardiac rhythm on the echocardiographic mitral valve area (MVA) and transmitral gradient calculation in relation to net atrioventricular compliance (Cn). METHODS Patients (n=22) with mild or moderate pure rheumatic mitral stenosis (MS) (MVA <2 cm2 and MVA >1 cm2) and atrial fibrillation (AF) were evaluated. All patients underwent t...

The Soil Conservation Service Curve Number (SCS-CN) approach is widely used as a simple method for predicting direct runoff volume for a given rainfall event. The CN parameter values corresponding to various soil, land cover, and land management conditions can be selected from tables, but it is preferable to estimate the CN value from measured rainfall-runoff data if available. However, previou...

Let φ : Cn×Cn → C, φ((x1, ..., xn), (y1, ..., yn)) = (x1−y1)+ ...+ (xn − yn). We say that f : Rn → Cn preserves distance d ≥ 0 if for each x, y ∈ Rn φ(x, y) = d implies φ(f(x), f(y)) = d. We prove that if x, y ∈ Rn (n ≥ 3) and |x − y| = ( √ 2 + 2/n)k · (2/n)l (k, l are nonnegative integers) then there exists a finite set {x, y} ⊆ Sxy ⊆ Rn such that each unit-distance preserving mapping from Sxy...

Reaction of Mo(2)Cl(4)(dppm)(2) (dppm = bis(diphenylphosphino)methane) with 6 equiv of [n-Bu(4)N][CN] or [Et(4)N][CN] in dichloromethane yields [n-Bu(4)N](2)[Mo(2)(CN)(6)(dppm)(2)] (1) and [Et(4)N](2)[Mo(2)(CN)(6)(dppm)(2)] (2), respectively. The corresponding one- and two-electron oxidation products [n-Bu(4)N][Mo(2)(CN)(6)(dppm)(2)] (3) and Mo(2)(CN)(6)(dppm)(2) (4)were prepared by reactions o...