The Drug Evaluation Classification (DEC) Program is used by Drug Recognition Expert (DRE) officers to determine whether a suspect is under the influence of a drug or drugs at the time of arrest, and, if so, what category of drug(s). The goal of this project was to investigate the relative importance of face-to-face interactions with the suspect, physical evidence (drugs or paraphernalia found),...

Morphine and related narcotic agonists produce mixed depressant and/or stimulant effects in a wide variety of animals including man (1,2) . These effects are not only species but also time and dose related . It is not gener ally appreciated that even a single dose of morphine in a given species, such as the rat, may have initial depressant and subsequent stimulant effects. We believe this is an...

The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated...

Aims To determine potentially significant drug interactions in an old age setting among inpatients with psychosis and medical comorbidities over the past 12 months Methods Study setting: inpatient functional ward Sample size: 11 Inclusion criteria: • Inpatients on psychotropic medications diagnosis ranging from F20 to F29 (ICD-10) Comorbid chronic condition(s) requiring long term treatment Excl...

we have studied the effect of amitriptyline, a tricyclic anti-depressant drug on several immune parameters of the balb/c mice in order to evaluate its immunomodulatory effects. results showed that amitriptyline will potentiates all of the immunocytes functions except for the production of pge2 by lps stimulated monocytes. we have also showed that amitriptyline can normalize the immunosuppressiv...

Office of Naval Research 11 ARSTRACT The question of the precise role of the heart in shock has been laroely unresolved. Previous separate reports have shown that both excitatory and depressant actions on the myocardium after endotoxin are observed. The purpose of the present study was to assay the possibility of a direct myocardial toxic aqtion of endotoxin or a circulatino mvocardial depressa...