Oligodendrocyte death contributes to the pathogenesis of the inflammatory demyelinating disease multiple sclerosis (MS). Nevertheless, current MS therapies are mainly immunomodulatory and have demonstrated limited ability to inhibit MS progression. Protection of oligodendrocytes is therefore a desirable strategy for alleviating disease. Here we demonstrate that enhancement of the integrated str...

Behçet disease is a chronic relapsing inflammatory condition, predominantly affecting young adults, characterised by recurrent bipolar aphtae and systemic manifestations for which tumour necrosis factor (TNF) alpha blockade has recently emerged as an effective treatment. We report the case of a patient presenting with mucocutaneous and ocular manifestations who in the course of his disease deve...

The depot formulation of liposomal cytarabine (DepoCyte) has proven to be useful as intrathecal (IT) treatment of neoplastic and lymphomatous meningitis. We report the results of compassionate use of DepoCyte in 6 patients diagnosed with acute leukemia (AL) and CNS involvement. Two patients had CNS involvement at diagnosis and the remaining 4 had CNS relapse. Three patients received DepoCyte as...

Central nervous system (CNS) nocardiosis is a rare disease entity caused by the filamentous bacteria Nocardia species. We present a case series of 5 patients from our hospital and a review of the cases of CNS nocardiosis reported in the literature from January 2000 to December 2011. Our results indicate that CNS nocardiosis can occur in both immunocompromised and immunocompetent individuals and...

Background and aims Pediatric acute lymphoblastic leukemia (ALL) survival rates in low- middle-income countries are lower due to deficiencies multilevel factors, including access timely diagnosis, risk-stratified therapy, comprehensive supportive care. This retrospective study aimed analyze outcomes for pediatric ALL at 16 centers Mexico. Methods Patients <18 years of age with newly diag...

Abstract BACKGROUND: ETV and tumor biopsy are central to the surgical management of children with primary CNS GCT. An creates a communication between intraventricular compartment subarachnoid spaces decompartmentalizes ventricular system. “Tumor spill” or shedding may result from interventions, such as biopsy. simultaneous impart greater tendency for dissemination possible distant relapse. This...

INTRODUCTION This study aims to assess the early tumour outcome and morbidity associated with radiation therapy (RT) in tumours of the central nervous system (CNS). MATERIALS AND METHODS Patients receiving RT with radical intent were entered on a prospective database. Tumour types were categorised into glioma, base of skull, pituitary, germ cell or primitive neuroectodermal tumour (PNET) and ...

The major event in relapsing remitting multiple sclerosis (MS) is the acute relapse. The majority of patients with MS present with such an event. Most early relapses are followed by complete or near complete recovery, however partial recovery or significant disability can result from an individual relapse. Study of relapses in vivo is therefore desirable. Magnetic resonance imaging (MRI) is ver...

PURPOSE A collaborative meta-analysis was performed to clarify the relative effects on relapse and survival of different types of therapies directed at the CNS in childhood acute lymphoblastic leukemia. MATERIALS AND METHODS Data were sought for each individual patient in all trials started in or before 1993 that included unconfounded randomized comparisons of such treatments. Log-rank surviv...