Blood platelets contribute to normal haemostasis in two main ways. They adhere to subendothelial microfibrils and collagen in the blood vessel wall, after which they change shape, undergo a specific release reaction, and aggregate with each other to form a primary haemostatic plug. As a consequence of these events, particularly during release and aggregation, procoagulant activities are generat...

Thrombophilic disorders encompass a diverse group of coagulation disorders that potentiate a predisposition for thrombotic events (e.g. deep vein thrombosis and pulmonary embolism). The term thrombophilia was coined in 1965 following a Norwegian familial study of venous thrombosis [1]. The entity of thrombophilia has also been described as a disorder in which there is abnormally, enhanced coagu...

Pathophysiological mechanisms of acute vascular thrombosis are not fully understood. It has been suggested that different infectious pathogens are responsible agents of thrombotic disorders. The infection hypothesis is supported by an increasing number of reports on the interaction between acute infection and coagulation. Cytomegalovirus (CMV) is supposed to play an important role in apparently...

Acute myocardial infarction (AMI) during pregnancy and puerperium is very rare. With a growing number of older women giving birth, AMI may become more common complication of pregnancy. We present a 42-year-old multipara with coagulation disorders in pregnancy who suffered from AMI in the peripartum period, documented by ECG, cardiac markers and echocardiography, with normal coronary arteries on...

The coagulation factor genes were among the first to be cloned and sequenced, beginning in the early 1980s. Now, in 2013, the detailed genetic structure of all of the identified constituents of the hemostatic process is well documented. The purpose of this minireview is to highlight current knowledge and the potential translational utility of genetic sequence information for 3 categories of ble...