BACKGROUND/AIMS The aim of the present study was to investigate whether Helicobacter pylori causes or triggers recurrent aphthous stomatitis (RAS) through cytokine gene polymorphism and/or cobalamin deficiency. MATERIALS AND METHODS Thirty-six patients with RAS and 130 patients without RAS were genotyped for IL-1β (-511C/T) and IL-6 (-174G/C) and evaluated for H. pylori infection and serum co...

It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and diseases. We report associations mainly with cancer, liver and kidney diseases, but...

BACKGROUND Combined methylmalonic aciduria and homocystinuria cobalamin C type (cobalamin C disease) is an inborn metabolic disorder consisting of an impaired intracellular synthesis of the 2 active forms of vitamin B12 (cobalamin), namely, adenosylcobalamin and methylcobalamin, that results in increased levels of methylmalonic acid and homocysteine in the blood and urine. Most patients present...

Vitamin B12 (cobalamin) deficiency is a major public health problem, particularly among the elderly population. It is known that a deficiency in serum B12 levels can cause a combination of neurological and psychiatric disorders. Therefore, in these cases successful replacement of depleted B12 levels is a necessity. Identification of B12 deficiency in elderly patients can be rather difficult as ...

It is well-established that more than 8% of patients examined for vitamin B12 deficiency unexpectedly have increased plasma levels of the vitamin, but so far there are no guidelines for the clinical interpretation of such findings. In this review, we summarise known associations between high plasma cobalamin and diseases. We report associations mainly with cancer, liver and kidney diseases, but...

A neonate, who was found to have an elevated C3/C2 ratio and minimally elevated propionylcarnitine on newborn screening, was subsequently identified as having the rare cblF inborn error of vitamin B12 (cobalamin) metabolism. This disorder is characterized by the retention of unmetabolized cobalamin in lysosomes such that it is not readily available for cellular metabolism. Although cultured fib...

The elderly have long been considered the primary target group for improved cobalamin nutrition. Cobalamin insufficiency has been associated with a variety of neurodegenerative conditions in this demographic group (1). However, there is mounting evidence that cobalamin deficiency is also associated with neurodevelopmental morbidity during infancy (2). In a simple, welldesigned, randomized doubl...

“The proscription that cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is akin to requiring jaundice to diagnose liver disease.” [1]. This statement by Carmel, one of the leaders in the vitamin B12 field, was made more than 10 years ago and yet many physicians and health authorities still insist on haematological changes before accepting a diagnosis of vitami...

Objective: Vitamin B12 deficiency can lead to serious health problems both in children and adult. Intramuscular injection therapy is applied as the gold standard treatment of vitamin deficiency. There are also oral, nasal, sublingual spray methods. In this study, we aimed show efficacy children. Materials Methods: Forty-five pediatric patients (25 boys, 20 girls), aged 9-36 months with serum co...