Despite 50 years of pharmacological and psychosocial interventions, schizophrenia remains one of the leading causes of disability. Schizophrenia is also a life-shortening illness, caused mainly by poor physical health and its complications. The end result is a considerably reduced lifespan that is marred by reduced levels of independence, with few novel treatment options available. Disability i...

OBJECTIVE The study aim was to characterize the time-course of recovery in impairments, activity limitations, participation restrictions, disability, and quality of life during the first year after cardiac arrest. Secondarily, the study described the associations between the instruments used to measure each of these domains. METHODS Measures of global disability (Cerebral Performance Category...

OBJECTIVE To evaluate the effectiveness of cognitive therapy for post-traumatic stress disorder related to terrorism and other civil conflict in Northern Ireland. DESIGN Randomised controlled trial. SETTING Community treatment centre, Northern Ireland. PARTICIPANTS 58 consecutive patients with chronic post-traumatic stress disorder (median 5.2 years, range 3 months to 32 years) mostly res...

OBJECTIVE To determine physical and cognitive outcomes of full-term infants who suffered intracranial hemorrhage (ICH) at birth. METHODS A retrospective hospital-based, follow-up study of infants treated in London, Ontario between 1985 and 1996. Follow-up was conducted by telephone interviews and clinic visits. Outcome was measured according to physical and cognitive scales. Perinatal risk fa...

PURPOSE This study used the Disablement Process Model to predict whether a sample of the oldest-old maintained their disability or disability-free status over a 2- and 4-year follow-up, or whether they transitioned into a state of disability during this time. DESIGN AND METHODS We followed a sample of 149 Swedish adults who were 86 years of age or older over a period of 4 years; we grouped th...

To the Editor: The neurobehavioral sequelae of traumatic brain injury significantly contribute to the longterm disability associated with this pathology. Thus far, there is insufficient evidence for either domainspecific or generalization effects resulting from cognitive intervention in memory, executive functioning, or speed-of-processing domains. Here, we report on the case of an adolescent p...

This article offers an introductory analysis of the philosophical and empirical considerations having to do with the significance of psychopathy, intellectual disability and ADHD regarding one’s moral responsibility. Moral responsibility comes in degrees and is ultimately determined on social grounds. Whether a certain diagnosis and its underpinning neuro-cognitive impairment affects one’s cogn...

Cognitive impairment is the main cause of disability in developed societies. New interactive technologies help therapists in neurorehabilitation in order to increase patients' autonomy and quality of life. This work proposes Interactive Video (IV) as a technology to develop cognitive rehabilitation tasks based on Activities of Daily Living (ADL). ADL cognitive task has been developed and integr...

OBJECTIVE To investigate accidental falls and near fall incidents in people with multiple sclerosis with respect to clinical variables and the predictive values of four tests. DESIGN A longitudinal, multi-centred cohort study with prospectively collected falls. PROCEDURES Self-reported incidents during the three months following a standardized test procedure. SUBJECTS Seventy-six people w...

OBJECTIVES Conventional magnetic resonance imaging (MRI) is used to diagnose and monitor inflammatory disease in relapsing remitting (RR) multiple sclerosis (MS). In the less common primary progressive (PP) form of MS, in which focal inflammation is less evident, biomarkers are still needed to enable evaluation of novel therapies in clinical trials. Our objective was to characterize the associa...