We report a case of colchicine-induced myopathy, in which the initial presenting and predominant clinical feature was respiratory muscle dysfunction; there was also chronic renal failure and electromyographically-measured myopathy. Discontinuation of colchicine led to marked improvement. Colchicine discontinuation was the only therapy performed (other medications were unchanged), and within 3 w...

INTRODUCTION One of the main reasons for disease recurrence in the curative breast cancer treatment setting is the development of drug resistance. Microtubule targeted agents (MTAs) are among the most commonly used drugs for the treatment of breaset cancer and therefore overcoming taxane resistance is of primary clinical importance. Our group has previously demonstrated that the microtubule dyn...

Results Renal amyloidosis (RA) revealed in 56 patients out of 83 (67%), who actually had never been treated by colchicine and FMF as well as amyloidosis were diagnosed initially on admission. 32.5% of FMF patients had other nephropathies: minimal change nephrotic syndrome (7); focal segmental glomerulosclerosis (7); acute postinfection glomerulonephritis (6); IgA nephropathy/Henoch-Schönlein ne...

Colchicine site-targeted tubulin inhibitors are a promising type of anticancer drugs. MT189 is a new derivative of MT119, a previously reported colchicine site-binding antitubulin agent. In this study, MT189 was demonstrated to retain the property of MT119 in disrupting microtubulin via binding to the colchicine site, causing mitotic arrest and inducing apoptosis, and to display 8.7-fold enhanc...

Using the whole-cell patch-clamp configuration in rat ventricular myocytes, we recently reported that microtubule disruption increases calcium current (I(Ca)) and [Ca(2+)](i) transient and accelerates their kinetics by adenylyl cyclase activation. In the present report, we further analyzed the effects of microtubule disruption by 1 micromol/L colchicine on Ca(2+) signaling in cardiac myocytes w...

Abstract Background/Introduction Colchicine has been shown to reduce inflammation and a potential stabilise atherosclerotic plaques. Prior meta-analyses on the topic suggest its role in reducing components of major adverse cardiovascular events (MACE). Purpose The aim present meta-analysis was delineate effect colchicine post-PCI (percutaneous intervention) MACE among acute coronary syndrome (A...

background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...

BACKGROUND Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limiting recurrent attacks of fever and serosal inflammation, leading to abdominal, thoracic or articular pain. OBJECTIVE To detect variable clinical presentations and genotypic distribution of different groups of FMF patients and the efficacy of colchicine therapy in treatment of these group...

The effect of colchicine on myogenesis in vivo has been studied in the regenerating tadpole tail of the frog, Rana pipiens, and in the abdominal molting muscles of a blood-sucking bug, Rhodnius prolixus Stål. Colchicine is shown to disrupt microtubules in the differentiating muscle cells of both these organisms. The disruption of microtubules is correlated with a loss of longitudinal anisometry...

Colchicine injection was used as a tool to potentiate the increase in intracellular lipoprotein lipase (type L hormone-sensitive lipase) activity normally seen with fasting to determine if elevation of enzyme activity by this method produced a reduction in endogenous triacylglycerol (TG) in rat heart. Both fasting and fasting+colchicine treatment increased total lipoprotein lipase (LPL) activit...