Erythrocyte survival studies of complement-coated radiolabeled erythrocytes have shown rapid removal of these cells from the peripheral blood with a return of these cells into the circulation within a few hours. We studied complement-coated human erythrocytes and measured surface charge and deformability, two parameters believed to be important in erythrocyte survival. Erythrocytes were coated...

When 11-day mice are fed with homologous or heterologous antibodies or with heterologous y-globulin, the maximum concentration of these proteins in their sera is reached 2 h later, irrespective of the amount or specificity of the proteins administered, or of the final con­ centration achieved. The relation between y (= relative titre of antibody, or concentration of heterologous y-globulin, att...

Conventional therapies for primary chronic cold agglutinin disease (CAD) are ineffective, but remissions after treatment with the anti-CD20 antibody rituximab have been described in a small, prospective trial and in some case reports. In this study we report on 37 courses of rituximab administered prospectively to 27 patients. Fourteen of 27 patients responded to their first course of rituximab...

Seven types of ferritinized lectin were used to examine the distribution of glycoconjugates on the outer segment membranes of lamprey photoreceptor cells. Ultrastructural pre-embedding labeling revealed that peanut agglutinin, soybean agglutinin and Ricinus communis agglutinin I were preferentially bound to the proximal, lateral and luminal surfaces of the long cell outer segments, whereas Grif...

The binding of [125I]wheat germ agglutinin ([125I]WGA) of high specific activity to Chinese hamster ovary (CHO) cells has been examined over a millionfold range of WGA concentrations and correlated with the phenomena of agglutination and capping by WGA. Analysis of the binding data by the method of Scatchard gives a complex curve indicative of positive cooperativity amongst high-affinity bindin...

Although the development of radiolabeled antibodies for preclinical and clinical use in PET imaging continues to mature into a widespread technique (1–4), limitations still remain: namely space, in which the antigens to which our antibody is targeting are located (intracellularly or cell surface, bound or circulating), and time, the extended period after which the imaging must take place, to al...

T HE discovery of so-called ‘ ‘incomplete’ ‘ or ‘ ‘blocking’ ‘ antibodies and of thermostable agglutinins reacting in serum or albumin but not in saline has stimulated discussion and speculation on their relation to each other and to the previously known Rh agglutinins which react in saline solution, and more recently on their relation to the various forms of fetal erythroblastosis. The problem...

Owing to unavoidable circumstances only a limited amount of time was available for the work on agglutination. The foregoing report is therefore preliminary only and the following conclusions are provisionally offered: I. Pneumococci by reason of their agglutinating properties exhibit a tendency to separate into numerous groups similar to streptococci. II. Pneumococcus mucosus forms a distinct a...

A previous study (15) has shown tha t transplantable mouse tumors differ in their capacity to grow progressively in rats pretreated with lyophilized mouse tumor tissue. An inverse correlation was found between the degree of strain specificity of tumors in mice and their transplantability to Pretreated rats. The present study deals with the correlation found between the transplantability of mous...