background: proliferation and expansion of cancer stem cells as spheroids were proved in previous studies. but, capability of primary tumor-derived stem cells to keep their unique properties in vitro is still disputed. so, the goal of this study was to isolate, expand and characterize of colon cancer-derived stem cells. material and methods: in the present work, colon cancer stem cells markers ...

background: in iran colorectal cancer (crc) incidence varies among various places. but we do not have any validate data that deeply explored the difference of crc in kerman province by national average. the aim of this study was to evaluate the incidence of colon cancer within a 12-year period in kerman province and to find whether the incidence of crc in kerman compared with the total incidenc...

background: leptin plays a key role in the regulation of energy expenditure and is known to circulate in both free and bound forms. soluble leptin receptor (sob-r) is a unique circulating form of leptin receptor that can bind to leptin. leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. our study was aimed to investigate the relatio...

abstract background: breast cancer is the most common cancer in women that as a sudden event has profound effects on all aspects of patients’ lives. psychosocial interventions may play important roles in reducing anxiety and depression among breast-cancer survivors. therefore, group training based on acceptance and commitment therapy may help women to cope better with their condition, and decre...

Nonsteroidal anti-inflammatory drugs (NSAID) have been associated with reduced risks of colon cancer, breast cancer, and other cancer sites (1, 2). We previously reported a strong inverse relationship between NSAID use and breast cancer in a North Carolina study, with a suggestion of stronger associations among African Americans (3). One hypothesized mechanism for the reduction in cancer risk b...

background: clinical and epidemiological variation was seen between the colon cancer (cc) and rectum cancer (rc). so, there is not so much data available about the epidemiological and clinicopathological differences and prognostic factors regarding to cc and cr in iran, we aimed to perform this study. methods: all cases of cc and rc referred to oncology and gastroenterology wards of taleghani g...

objective: the incidence of breast cancer is approximately one million which makes this cancer one of the most common among women worldwide. breast cancer comprises 7% of the total death rate caused by cancers. several strategies that use tumor-associated antigen (taa) vaccination and early detection of breast cancer are clinically being developed. breast cancer is caused by increased over expr...

BACKGROUND Human X-box binding protein 1 (XBP-1) is a transcription factor essential for hepatocyte growth, as well as for plasma cell differentiation. Recently, overexpression of XBP-1 has been reported in breast cancer including non-invasive carcinomas, and was suggested to play an important role in breast carcinogenesis. To investigate the involvement of XBP-1 in colorectal tumorigenecity, t...

ABSTRACT           Breast cancer remains the most common cancer of women and one of the most common causes of cancer-related deaths worldwide. In spite of major advances in breast cancer diagnosis and treatment, the incidence of breast cancer remains high and the treatment of metastatic breast cancer remains challenging. This review presents an over...