نتایج جستجو برای: colon cancer cells
تعداد نتایج: 2121957 فیلتر نتایج به سال:
Colon cancer is the third most commonly diagnosed in men worldwide. grows slowly and metastasis has already occurred after diagnosis. Therefore, new targets are needed colon treatment Transmembrane proteins (TMEM) play a critical role presents different expression profile variety of tumor cells. TMEM106C TMEM family protein, but its on development unknown. In this study, we aimed to investigate...
colon cancer is cancer of the large intestine (colon), the lower part of digestive system and the third most common cancer in men and the second most common cancer in women worldwide. genetic background is thought to play a role in modulating individual risk to this cancer. many studies support an association for insulin pathway gene polymorphisms and the regulation of tumor cell biology in c...
Transmembrane 4 superfamily member 5 protein (TM4SF5) is presumed to serve as a molecular target to prevent or treat hepatocellular carcinoma (HCC) and colon cancer in a mouse model. Previously, we reported the efficacy of anti-cancer peptide vaccine targeting TM4SF5. In addition, we reported an anti-proliferative effect of anti-TM4SF5 monoclonal antibody in HCC. Here, we investigated expressio...
Lipid droplets, the dynamic organelles that store triglycerides (TG) and cholesterol esters (CE), are highly accumulated in colon cancer cells. This work studies TG CE subspecies profile carcinoma cell lines, SW480 derived from primary tumor, SW620 a metastasis of same tumor. It was previously reported total content is dramatically higher cells; however, has not been investigated detail. The pr...
Colon cancer is the third most common malignancy worldwide, and chemotherapy is a widely used strategy in clinical therapy. Chemotherapy-resistant of colon cancer is the main cause of recurrence and progression. Novel drugs with efficacy and safety in treating colon cancer are urgently needed. Shikonin, a naphthoquinone derived from the roots of the herbal plant Lithospermum erythrorhizon, has ...
MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The ...
Colorectal cancer is the third most common cancer world wide and has been occurred more in developing regions. The use of conventional chemotherapy agents may lead to various adverse effects. Therefore, it is required to find the potential drug for anticancer from alternative source of natural product including mangrove plants. The present study was conducted to determine the anticancer activit...
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BACKGROUND "Cancer stem cells" (CSC) have been identified as a minority of cancer cells responsible for tumor initiation, maintenance and spreading. Although a universal marker for CSC has not yet been identified, CD133 has been proposed as the hallmark of CSC in colon cancer. The aim of our study was to assess the presence of a CD133+ cell fraction in samples of colon cancer and liver metastas...
OBJECTIVES Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted to investigate the impacts of apatinib on the biological function and its potential mechanism of colon cancer cells in vitro. MATERIALS AND METHODS The effect of apatinib in colon cancer cells were detected by assessing cell v...
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