The prospective clinical examination of 80 patients with the verified carcinoma of the colon and rectum was performed at the Clinic of General and Vascular Surgery of the M.M.A. in the period 1989-1990 with the aim to evaluate efficacy and justified use of antibiotic prophylaxis or prophylaxis and antibiotic therapy after elective surgical intervention. The preoperative mechanical preparation w...

Colon carcinogens produce a variety of nuclear anomalies including pyknotic, karyorrhectic, and micronucleated cells in the colonie epithelium within a few hr. Two model carcinogens, 1,2dimethylhydrazine and 7-rays, have been used to determine appropriate techniques, conditions, and scoring critiera for de tecting such nuclear anomalies most efficiently. The results show that a rapid and sensit...

Colon carcinogens produce a variety of nuclear anomalies including pyknotic, karyorrhectic, and micronucleated cells in the colonic epithelium within a few hr. Two model carcinogens, 1,2-dimethylhydrazine and gamma-rays, have been used to determine appropriate techniques, conditions, and scoring criteria for detecting such nuclear anomalies most efficiently. The results show that a rapid and se...

The presence of synchronous multiple primary carcinomas, although recognized, remains very uncommon. Their etiopathogeny is unclear. The wide spread of imaging techniques currently facilitates diagnosis of simultaneous tumors. We present the rare case of a signet ring cell colon carcinoma coexisting with a transitional cell carcinoma (TCC) of the ureter, which debuted with symptoms of intestina...

Introduction Colorectal cancers are the third most common type of cancers globally, affecting both sexes [1]. As of now, histopathology is the gold standard method for colon cancer diagnosis. Newer technologies are the important need of the hour to complement the existing approaches, for better understanding the onset and progression of the disease. Infrared (IR) imaging could be a potential ca...

Virtual colonoscopy is a non-invasive technique for the detection of polyps. Currently, a clean colon is required; as without cleansing the colonic wall cannot be segmented. Enhanced bowel preparation schemes opacify intraluminal remains to enable colon segmentation. Computed cleansing (as opposed to physical cleansing of the bowels) allows removal of tagged intraluminal remains. This paper des...

background and aims: among all cancers, colon cancer is common and deadly, yet preventable. the estimated worldwide incidence of colon cancer is more than one million new cases per year. this study was done to identify the epidemiological features and risk factors of colon cancer in different regions of birjand. methods: this retrospective, descriptive analytical study of patients with colon ca...

The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. The aim of this study was to prepare new low methoxy amidated pectin/NaCMC microspheres cross-linked by a mixture of Zn(2+) and Al(3+) ions and test their potential for colonic targeting of progesterone. A 2(4) factorial design was carried out to optimize the preparation conditions. Hi...

Submucosal cholinergic and noncholinergic neurons in intestines have been shown to be involved in regulating epithelial transport functions, particularly stimulating Cl(-) secretion. This study investigates the role of submucosal cholinergic neurons in regulating electrogenic Na(+) absorption in distal colon. Amiloride-sensitive short-circuit current (I(sc)) and (22)Na(+) flux were measured in ...

Background Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability to selectively accumulate in inflamed colonic mucosa. Cyclosporine A (CSA), an immunosuppressive agent, has long been used as rescue therapy in severe steroid-refractory UC. In this study, we developed CSA-loaded dual-functional polymeric NP...