background: poisoning, a common worldwide problem, seeks its own treatments to improve, especially by the forthcoming evidence based medicine (ebm). charcoal/sorbitol slurry (css) administration is one of these methods with great debates around it which needs to be investigated more. methods: in this clinical trial, 105 cases of benzodiazepine toxicity with at least 3 symptoms and no contraindi...

BACKGROUND Carcinoid diarrhoea is associated with rapid small bowel and proximal colonic transit. Intravenous administration of a serotonin type 3 receptor (5HT3) antagonist restores postprandial colonic tone towards normal in carcinoid patients. AIMS To evaluate the medium-term effects of an oral 5HT3 antagonist, alosetron, on symptoms, stool fat, and transit in patients with carcinoid diarr...

Colon specific drug delivery has gained increased importance not just for the delivery of drugs for the treatment of local diseases associated with the colon but also as potential site for the systemic delivery of therapeutic peptide and proteins. To achieve successful colon targeted drug delivery, a drug needs to be protected from degradation, release and/or absorption in the upper portion of ...

Majority of the million plus cities in India are facing serious problems of traffic congestion and pollution due to the unprecedented and rapid pace of urbanization in last decade. City planners are providing solution to these twin problems by developing Mass Rapid Transit System including Metro and BRT in many Indian Metropolitan cities. The availability of transit network and pedestrian acces...

Although it is well documented that the gut microbiota plays an important role in health and disease in mammalian species, this area has been poorly studied among carnivorous animals, especially within the mustelidae family. The gastrointestinal tract of carnivores is characterized by its short length and fast transit time, as compared to omnivores and herbivores, which is due to the low level ...

Figure. Asscoiation with psychosocial factors. There is a significant difference in the mean value for global scale index between rectal hyposensitivity and normosensitive group. GSI, global scale index; PSDI, positive symptom distress index; PST, positive symptom total. TO THE EDITOR: We read with interest the review article by Burgell and Scott regarding rectal hyposensitivity (RH). RH is cli...

250 words) 41 Genetic variations in metabolism of endocannabinoids and in CNR1 (gene for cannabinoid 1 42 receptor) are associated with symptom phenotype, colonic transit, and left colon motility in 43 irritable bowel syndrome (IBS). Our aim was to evaluate associations between two variations in 44 CNR1 genotype (rs806378 and [AAT]n triplets) with symptom phenotype, small bowel and 45 colonic t...

Genetic variations in metabolism of endocannabinoids and in CNR1 (gene for cannabinoid 1 receptor) are associated with symptom phenotype, colonic transit, and left colon motility in irritable bowel syndrome (IBS). Our aim was to evaluate associations between two variations in CNR1 genotype (rs806378 and [AAT]n triplets) with symptom phenotype, small bowel and colonic transit, and rectal sensati...

BACKGROUND Existing data on the effect of ageing on gastrointestinal motility are few. In this study, we assessed the propulsive effect of all main segments of the gastrointestinal tract in a group of healthy older people. METHODS 16 healthy volunteers (eight women, eight men) of mean age 81 years (range 74-85 years) participated in the study. Gastric emptying and small intestinal and colonic...