The human colon has the capacity to secrete potassium (K(+)) ions and enhanced K(+) secretion is a feature of a variety of diarrhoeal diseases. Recent work points to K(+) secretion in human colon being mediated by high conductance (BK) K(+) channels located in the apical membrane of colonic epithelial cells. The aim of this review is to highlight the importance of these channels in maintaining ...

Open Access Colonoscopy has been widely used as a screening modality for colorectal cancer and in the treatment of colon disorders. Generally, colonoscopy is safe, well tolerated, and recognized as a standard diagnostic and treatment method for colon disorders. Cecal intubation (CI) is one of the proposed quality indicators for colonoscopy.

BACKGROUND It has been suggested that phospholipase A2 (PLA2) has an essential role in the pathogenesis of inflammatory bowel diseases. AIMS This study aimed at identifying cells in intestinal and mesenteric tissue samples that might express group II phospholipase A2 (PLA2-II) at the mRNA and enzyme protein levels in patients with ulcerative colitis. PATIENTS AND TISSUE SAMPLES: Tissue sample...

Introduction and purpose Microscopic colitis is multicausal inflammatory bowel disease, which affects mostly elderly, particularly women. It a cause of chronic, watery diarrhea. MC usually presents macroscopically normal, thus diagnosis requires colonoscopy histological examination colonic biopsies. doesn’t increase risk colon cancer. However, it leads to impaired patients’ quality life reduced...

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Defining the pathophysiology of chronic constipation is critical for planning management...

Background: Pediatric colonoscopy is a safe, sensitive and crucial tool for diagnosing as well treating children with lower gastrointestinal diseases. In resource-limited countries like Bangladesh, the practice of pediatric remains rudimentary, lacking in trained professionals appropriate instrumentation.
 Objectives: The aim study was to find out indications, common colonoscopic findings ...

A retrospective study of Crohn's disease has been carried out in Clydesdale covering the decade 1961-1970. Three hundred and fifty-seven patients had acceptable evidence of either acute ileitis or of chronic granulomatous bowel disease. Of those fulfilling the criteria for inclusion in the study of chronic disease, 95% had accurate pathological and/or operative documentation of the lesions. Ove...

Inflammatory bowel diseases (IBDs) are chronic inflammatory that often relapse and divided into two types, Crohn’s disease (CD) ulcerative colitis (UC). Histopathological findings in colonic mucosal biopsy with clinical diagnosis suspicious IBD can vary overlap. Therefore, criteria guidelines have been created to improve the diagnostic accuracy. This descriptive observational study was performe...