PURPOSE Mucins are members of the glycoprotein family expressed in benign and malignant epithelial cells. The aim of this study is to evaluate the relationships between the expression of mucins in breast ductal carcinoma and clinicopathologic parameters. METHODS We constructed tumor microarrays based on 240 cases of invasive ductal carcinoma and 40 cases of ductal carcinoma in situ (DCIS) usi...

The best Chinese offshore software service outsourcing (SSO) vendors are seen to be growing rapidly while dynamically adjusting their global position in their extended value networks. These organisations can be categorised as born-global firms, namely, organisations that are born with a clear goal to seek superior international performance from the application of knowledge-based resources to th...

INTRODUCTION In development of novel therapies for the treatment of patient with cancer, the use of radiotherapy (RT) can produce significant local control and, in recent studies, has also been shown to mediate anti-tumor responses at distant sites by triggering and enhancing the endogenous cellular immune responses. Although RT induces an abscopal effect in some patients due to enhanced immune...

In this paper, Pinellia ternata lectin (PTL) purified from 95% saturated ammonium sulfate precipitation by applying mannose-Sepharose 4B affinity column chromatography was first described. The mannoseSepharose 4B affinity adsorption gel has already been designed and prepared before the experiments according the combinative characterization between lectin and mannose. Mass spectrometry analysis ...

For the purpose of obtaining high bone forming efficacy, development of chitosan was attempted as a tool useful as a scaffolding device. Porous chitosan matrices, chitosan-poly(L-lactide) (PLLA) composite matrices and chitosan coated on PLLA matrices were dealt with in this research. Porous chitosan matrix was fabricated by freeze-drying and cross-linking aqueous chitosan solution. Porous chito...

The performance gap for high performance applications has been widening over time. High level program transformations are critical to improve applications’ performance, many of which concern the determination of optimal values for transformation parameters, such as loop unrolling and blocking. Static approaches achieve these values based on analytical models that are hard to achieve because of ...

P-glycoprotein (Pgp) is one of the active efflux pumps that are able to extrude a large variety of chemotherapeutic drugs from the cells, causing multidrug resistance. The conformation-sensitive UIC2 monoclonal antibody potentially inhibits Pgp-mediated substrate transport. However, this inhibition is usually partial, and its extent is variable because UIC2 binds only to 10 to 40% Pgp present i...

Currently, there is no cure for the permanent vision loss caused by degenerative retinal diseases. One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine. The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye. The success of transplant...

This paper presents a new methodological approach for analysing the impacts of climate change on urban habitat and improving quality life citizens. The study falls within diagnostic phase Climate Change Urban Health Resilience (CCUHRE) research project applied to rationalist neighbourhood Monticelli, suburb Ascoli Piceno (Italy). tests innovative multidisciplinary cognitive tools quantify creat...