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Herein we present a new application of a recently demonstrated fully synthetic "phage-like" system for screening of combinatorial mixtures in a live cell assay. The new application includes the direct synthesis of peptides and combinatorial libraries on 2 μm cross-linked mono-dispersed microspheres bearing a panel of fluorescence tags. Their characterization using classical chemical analysis as...

Real world combinatorial optimization problems such as scheduling are typically too complex to solve with exact methods. Additionally, the problems often have to observe vaguely speci ed constraints of di erent importance, the available data may be uncertain, and compromises between antagonistic criteria may be necessary. We present a combination of approximate reasoning based constraints and i...

One of the challenges of combinatorial chemistry is the selection of compounds to synthesise. Usually a full combinatorial set will generate large numbers of compounds but at the expense of diversity and in some cases might generate compounds that represent extremes of molecular weight and lipophilicity. Various methods have been employed to improve the quality of library design, and the genera...