OBJECTIVE We aimed to study the association among ABO blood group, von Willebrand factor, factor VIII plasma levels, and the risk of venous thrombosis (VT) in a cohort of 1774 relatives from 500 families with inherited thrombophilia. METHODS AND RESULTS One hundred sixty-one of the 1774 relatives had a VT. Different risk groups were formed: no, low-(factor V Leiden or F2G20210A heterozygous c...

Two patients with hemophilia A and antiquential antibody titers demonstrated no factor VIII antibodies were treated with change in antibody response in either infusions of factor VIII concentrates and patient when compared to previous studintravenous cyclophosphamide in an aties following factor VIII infusion alone. tempt to suppress the antibody response. These results are in contrast to the p...

Thrombophilia involves genetic and acquired conditions that increase the risk of venous thromboembolism (VTE). During the last decade, the identification of thrombophilic defects has increased from less than 10% to approximately 50% of patients presenting with unprovoked VTE. The factor V Arg506Gln (factor V Leiden) and the prothrombin G20210A mutations are the most prevalent abnormalities, fou...

There are three major types of VWD disease. Type 1, the most frequent form, is characterized by a partial quantitative deficiency in von Willebrand factor (VWF). Type 2 is a qualitative deficiency, and Type 3 is a virtually complete deficiency. Type 2 VWD is divided into four subtypes. Type 2A includes variants with decreased platelet adhesion caused by a selective deficiency in high-molecular ...

In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS patients and 92 PVT patients with 474 population-based controls. The relative risk of BCS was 11.3 ...

A spectrophotometric study of osmium (VIII) complex of 1-hydroxy 2- pyridine thione (HPT) is presented. A red-violet complex, 0 s (HPT) is formed in a highly acidic solution, and shows maximum absorbance at 500 nm with molar absorptivity of 5.12 x 101. mol . cm . Beer's law is obeyed in the range of 3-60 ppm. Sandel's sensitivity of the method is 0.37 ?g.cm per0.001 ab sorbance unit. V (V)...

In a collaborative multicenter case-control study, we investigated the effect of factor V Leiden mutation, prothrombin gene mutation, and inherited deficiencies of protein C, protein S, and antithrombin on the risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We compared 43 BCS patients and 92 PVT patients with 474 population-based controls. The relative risk of BCS was 11.3 ...

Within the last 18 months, we have noted the development of unexplained lymph node enlargement in otherwise asymptomatic patients with hemophilia. Because such changes are poorly understood and, in some patient groups, may be related to the acquired immunodeficiency syndrome (AIDS), we studied the enlarged lymph nodes in four patients with severe factor VIII deficiency and abnormally low periph...