This study was performed to determine whether synthetic ascorbic acid (AA) alone or in a natural citrus extract containing bioflavonoids, proteins, and carbohydrates was more bioavailable to human subjects. The effect of a single 500-mg ascorbate dose of the two forms and a placebo citrus extract on plasma ascorbate was examined in eight fasting subjects. A comparison of the areas under the pla...

This study was aimed to investigate the bioequivalence of ibuprofen 125 mg suppository formulation (Ibukal®, test formulation from PT. Kalbe Farma, Tbk., Jakarta) and the ibuprofen suppository comparative formulation (Proris®, from PT. Pharos Indonesia, Jakarta) in 12 healthy volunteers. The pharmacokinetic parameters used in this study were the area under the concentration-time curve from time...

Signal transducers and activators of transcription (STATs) facilitate action of cytokines, growth factors and pathogens. STAT activation is mediated by a highly conserved SH2 domain, which interacts with phosphotyrosine motifs for specific STAT-receptor contacts and STAT dimerization. The active dimers induce gene transcription in the nucleus by binding to a specific DNA-response element in the...

this study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy indian male subjects. this single-dose, randomized, open-label, 2-period crossover study was carried out in 12 healthy indian male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days.  the subjects were randomly assigned to receive the test...

knowledge of the probable origin and behaviour of arsenic certainly gives valuable insights into the potential for transfer in the environment and of the risks involved in mining sites. sequential extraction analyses are common experiments often used to study the origin and behaviour of potentially toxic elements. the method, however, presents some deficiencies, including labor-intensive proced...

For an accurate risk assessment of sites contaminated by trace elements (TE), measurements of bioavailability must be performed. This is routinely achieved using the standardized 0.01M CaCl2 method. However, the suitability of chemical extractions as proxies of bioavailability is questionable. We analyzed the correlations between chemically estimated TE bioavailability and TE actually accumulat...

The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

Objective: To determine the bioequivalence of two marketed test formulations (A, B) as compared to a reference formulation (R) of slow release theophylline in healthy volunteers. Material and Methods: The study was conducted as an open label, balanced, randomized, threetreatment, three-period, three-sequence single-dose crossover study to determine the bioequivalence of Phylobid 200 mg SR table...

OBJECTIVE To evaluate the bioavailability and pharmacokinetics of orally administered tapentadol immediate release (IR) compared with tapentadol prolonged release (PR). METHODS Three randomized, open-label, crossover studies were conducted in subjects under fasted conditions. Studies 1 and 2 determined the absolute bioavailability and pharmacokinetics of oral tapentadol IR 86 mg and tapentado...