Optical biosensors are often used to measure kinetic rate constants associated with chemical reactions. Such instruments operate in the surface-volume configuration, in which ligand molecules are convected through a fluid-filled volume over a surface to which receptors are confined. Currently, scientists are using optical biosensors to measure the kinetic rate constants associated with DNA tran...

We present a simple, two-component model for the charged mu'ltiplicity associated with the observed particle in an inclusive reaction. At small p T' the scattering is ascribed to a coherent or I* soft " component, whereas at large pT the production mechanism is assumed to be incoherent or " hard. l1 At fixed incident energy and missing mass, the pT-dependence of Kc is given by the relative weig...

We present a multistep direct reaction theory for analyzing nucleon-induced reactions to the continuum for incident energies up to 200 MeV. Two principal advances in multistep direct theory are studied: (1) A microscopical approach for calculating DWBA transitions to the continuum, where transitions to all accessible 1p1h shell model states are explicity determined; (2) A two-component formulat...

The analysis of kinetic data monitored using spectroscopic techniques and its resolution into its unknown components is described. Independent Component Analysis (ICA) can be considered a calibration free technique with the outcome of the analyses being the spectral profiles of the unknown species. This enables the realisation of qualitative information concerning the identification of the numb...

We consider deep-inelastic lepton scattering, Drell-Yan lepton pair and heavy quark production in the reference frame of the target. These reactions traditionally treated as hard have, however, a substantial leading twist soft contribution. One of the manifestations of such a soft component, nuclear shadowing, is overviewed. ∗Invited talk at the Workshop Hirschegg’95: Dynamical Properties of Ha...

We describe a cloning strategy, third irrelevant enzyme site (TIES), based on three-component assembly ligation reactions to overcome seven types of problematical cloning reactions. Implementation of the TIES strategy has made it possible to obtain the desired recombinant where the corresponding approach using conventional recombinant DNA methodologies and two-component ligations failed to give...

Evidence is presented which shows that there is a component present in normal allantoic fluid, probably mucoprotein in nature, capable of combining with influenza A virus (PR8), and that following combination between this component and the virus only partial dissociation of the complex occurs. Evidence is also presented which strongly suggests that the component is present in virus-infected all...

The melanocortin system is composed of the melanocortin peptides, adrenocorticotropic hormone and alpha-, beta-, and gamma-melanocyte-stimulating hormone, the melanocortin receptors (MCRs), and the endogenous antagonists agouti- and agouti-related protein. Melanocortin peptides exert multiple effects upon the host, including anti-inflammatory and immunomodulatory effects. Leukocytes are a sourc...

A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions us...