Apparent mineralocorticoid excess (AME) syndrome is a rare autosomal recessive disorder due to the deficiency of 11b hydroxysteroid dehydrogenase type 2 enzyme (11beta-HSD2). Mutations in this gene affect the enzymatic activity resulting to an excess of cortisol, which causes its inappropriate access to mineralocorticoid receptor leading to inherited hypertension.This is a potentially fatal but...

The electronic structure of boron-hydrogen complex and boron pair in diamond are studied by first-principles density-functional calculations with supercell models. The electronic structure calculated for the B-H complexes with C2v or C3v symmetry and the nearest-neighbor B pair is used to interpret recent experimental results such as B 1s x-ray photoemission spectroscopy, 11B nuclear quadruple ...

a ( ) Brain Sciences Center 11B , Veterans Affairs Medical Center, Minneapolis, MN 55417, USA b Department of Physiology, UniÕersity of Minnesota Medical School, Minneapolis, MN, USA c Department of Neurology, UniÕersity of Minnesota Medical School, Minneapolis, MN, USA d Center for Magnetic Resonance Research, UniÕersity of Minnesota Medical School, Minneapolis, MN, USA e Department of Radiolo...

A green chemistry approach has been adopted for the synthesis of thirty-four new picolinium-based ionic liquids using microwave (MW) and ultrasound (US) irradiation as well as conventional thermal heating. Their structures were confirmed by FT-IR, 1H NMR, 13C NMR, 11B NMR, 19F NMR, 31P NMR, mass spectra and elemental analyses. The antimicrobial profile of the novel ionic liquids was evaluated a...

Modification of the C-1 ketone of salvinorin A (2a) produces analogues with opioid antagonist properties. Of particular significance is the finding that 1-deoxo-1,10-dehydrosalvinorin A (11a) is a moderately potent antagonist at all three opioid receptor subtypes, and that herkinorin (2b), a mu agonist, is converted to a weak antagonist by removal of the C-1 ketone (3b and 11b). These observati...

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

The feasibility of positive energy yield in systems with the p–11B reaction is considered here by considering refined (optimistic) data on rate. analysis was carried out within traditional framework for magnetic confinement systems, but without taking into account a particular type plasma configuration. balance both ions and electrons. particles includes all species as well products fusion (alp...

Abstract Hepatocellular carcinoma (HCC), also known as hepatoma, is the most prevalent type of primary liver cancer. It begins in hepatocytes, liver’s major cell type. Cancer that began another region body but has spread to secondary cancer life; several still unmet demands for better, less toxic therapy treat this malignant tumor. Several novel pyrazolo[1,5- a ]pyrimidine derivatives were synt...

Abstract. Constraints on the evolution of atmospheric CO2 levels throughout Earth's history are foundational to our understanding past variations in climate. Despite considerable effort, records vary their temporal and spatial coverage estimates do not always converge, therefore new proxies valuable. Here we reconstruct values across major climate transitions over 16 million years using boron i...