Introduction Computer Based Learning (CBL) is a field of growing interest in the University and in schools of any degree, but the availability of effective CBL products (H. Anton, R. Larson et al.), is limited by some critical factors: the difficulty to define the full structure (contents, static and dynamic aspects) of the electronic book; the difficulty for the teachers to adapt the form of t...

Cobalamin (Cbl, vitamin B(12)) serves for two essential cofactors in mammals. The pathway for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors and three Cbl-transporting proteins, haptocorrin, intrinsic factor, and transcobalamin (TC). We present the structure determination of a member of the mammalian Cbl-transporter family. The crystal structures of...

background: according to the available evidence and experiments, problem-based learning is one of the most successful methods to achieve higher educational objectives. in this method, the discussion about the medical sybjects to be learned by the students is based on a real clinical case and participation of the students. various advantages and disadvantages of this method have been addressed i...

The growth of the mobile phone market has been generating a great demand for professionals qualified applications (APPs) development. required profile includes technical skills, also known as hard and behavioral or soft skills. training these in speed, quantity, quality demanded by poses significant challenge educational institutions. Apple PUCPR have established partnership to build software s...

The Cbl family of ubiquitin ligases in mammals contains three members, Cbl, Cbl-b, and Cbl-3, that are involved in down-regulation of receptor tyrosine kinases (RTKs) by mediating receptor ubiquitination and degradation. More recently, a novel pathway has been identified whereby Cbl promotes internalization of EGF receptor via a CIN85/endophilin pathway that is functionally separable from the u...

Cobalamin (Cbl; vitamin B(12)) malabsorption in pancreatic insufficiency can be partially corrected by bicarbonate and completely corrected by pancreatic proteases but the mechanisms involved are unknown. Because saliva contains enough R-type Cbl-binding protein (R protein) to bind all of the dietary and biliary Cbl, it is possible that R protein acts as an inhibitor of Cbl absorption and that ...

O uso da metodologia ativa no ensino Odontologia é recomendado nas Diretrizes Curriculares Nacionais, com a finalidade de desenvolver habilidades e competências, assim como estimular capacidade reflexiva dos egressos. Em Prótese Parcial Removível (PPR), alguns estudos apontam os benefícios do método centrado aluno, utilizando diferentes estratégias, Problem-Based Learning (PBL), Case-Based (CBL...

Cobalamin (Cbl, vitamin B-12) has been extracted and isolated from a number of animal tissues by using (i) reverse-affinity chromatography on R protein-Sepharose followed by adsorption to and elution from charcoal-coated agarose and (ii) paper chromatography. Radioisotope dilution assays showed that only 75-97% of the Cbl chromatographed in the position of crystalline Cbl. The remaining 3-25% w...

The Cbl family of proteins negatively regulate signaling from tyrosine kinase-coupled receptors. Among the three members of this family, only c-Cbl and Cbl-b are expressed in hemopoietic cells. To examine the role of c-Cbl and Cbl-b in Fc epsilon RI signaling, mast cell cultures from wild-type, c-Cbl(-/-), and Cbl-b(-/-) mice were generated. Cell growth rates and cell surface expression of Fc e...