BACKGROUND Up to 90% of neonates with congenital or perinatal cytomegalovirus (CMV) infection are asymptomatic, and little is known about CMV-associated thrombocytopenia after the neonatal period. We investigated the clinical findings of a series of infants diagnosed with CMV infection and thrombocytopenia. METHODS From July 2005 to July 2008, infants aged younger than 6 months with thrombocy...

OBJECTIVE To determine the ability of neonatal clinical, audiologic, and computed tomography (CT) findings to predict long-term neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection. METHODS Longitudinal cohort study of children (n = 41) with symptomatic congenital CMV infection evaluated at birth and followed up with serial age-appropriate neurode...

BACKGROUND Although cytomegalovirus (CMV) is an uncommon cause of viral hepatitis during pregnancy, a definitive diagnosis is important because of the potential for congenital CMV. In the case reported here, a diagnosis of hepatitis caused by CMV was made after the more common viral pathogens had been ruled out. CASE A 17-year-old, 12-week pregnant patient was evaluated for fever and right up...

HIV related cytomegalovirus (CMV) disease results from reactivation of latent infection when the CD4 count falls below 100 cells ×10/l. Before the introduction of highly active antiretroviral therapy (HAART) up to 40% of HIV infected patients developed CMV disease, predominantly retinitis. Early diagnosis of retinitis may result in a better response to therapy and reduced loss of vision. As ret...

Fetal and neonatal infections caused by human cytomegalovirus (CMV) are important causes of morbidity and occasional mortality. Development of a vaccine against congenital CMV infection is a major public health priority. Vaccine design is currently focused on strategies that aim to elicit neutralizing antibody and T-cell responses, toward the goal of preventing primary or recurrent infection in...

Introduction: Human Cytomegalovirus (HCMV) or Human Herpes Virus Type-5(HHV-5) is a member of herpesviridae placed in subtype beta herpesvirinae. CMV is a ubiquitous pathogenic virus and can infect humans all through their life. Prevalence of CMV infection in developed countries is about 45% and in developing countries it varies up to 100%. CMV infection during pregnancy is very important, beca...

BACKGROUND Cytomegalovirus (CMV) is a common opportunistic infection among HIV-infected individuals, a major source of serious complications among organ-transplant recipients, and a leading cause of hearing loss, vision loss, and mental retardation among congenitally infected children. Women infected for the first time during pregnancy are especially likely to transmit CMV to their fetuses. Mor...

Congenital cytomegalovirus (CMV) infection causes severe disabilities and developmental delays. Women's awareness of CMV is low. Only about half of healthcare providers report counseling women about behaviors to reduce CMV risk and public health education is limited. Routine CMV counseling is not recommend. Providers may lack time to counsel women; other conditions may take priority for counsel...

BACKGROUND Congenital cytomegalovirus (cCMV) infection contributes to considerable long-term sequelae in neonates and children all over the world. The association between viral genotypes and severity of clinical cytomegalovirus (CMV) infection is yet to be defined. The objective of this study was to find the impact of active CMV infection during pregnancy and the clinical significance of genoty...

w w w. o b g m a n a g e m e n t . c o m For the 2006 Update, I have chosen to focus on 3 important new clinical reports that stand to improve patient care, and another development that necessitates a change in how we treat gonorrhea in pregnant women: CMV vaccine. A new immunologic agent for the treatment and prevention of congenital cytomegalovirus (CMV) infection is extremely promising. Unti...