Truncus arteriosus is a rare, cyanotic, and congenital heart defect occurring due to failure in the differentiation of aorta pulmonary artery during fetal development. The disease categorized into four sub-categories Van Praagh Collett & Edwards classification systems according origin arteries. Surgical correction arteries repair ventricular septal preferred treatment strategy choice; this ...

Complex congenital heart defects (CHD) are associated with a variety of single gene abnormalities and chromosomal rearrangements. Of the various forms of CHD, aortic arch interruption, a conotruncal heart defect, is relatively uncommon. Here we report a male neonate with aortic arch interruption type B, secundum atrial septal defect, perimembranous ventricular septal defect, patent ductus arter...

A retrospective analysis of case-records data of 53,653 patients (0-18 years) over a two and half year period was conducted to ascertain the spectrum of congenital heart diseases. Two hundred and twenty one patients were found having congenital heart diseases; a prevalence of 4.1/1000. Ventricular septal defect (VSD) was the most frequent lesion seen in 69 (31.2%), followed by patent ductus art...

We have reviewed data on all patients born between 1960 and 1969 and registered in the Liverpool Registry of Congenital Malformations as having congenital heart disease. There were 385 with a ventricular septal defect as their sole or main cardiac lesion. Analysis of the available follow-up data showed that 50 of these were subsequently assigned in other diagnostic categories and a further 41 f...

Success of surgical repair of congenital heart defects in the past five decades has enabled survival into adulthood. Women born with congenital heart diseases reach child-bearing age with or without surgical repair of those lesions. Specifically, atrial septal defect (ASD) is a non-lethal, acyanotic lesion in which survival into adulthood with or without surgery is common place. Types of ASD an...

Pulmonary vascular structure was studied by analysing serial reconstructions of the arterial pathways and random sections of tissue in the lungs of 16 children who died with different types of congenital heart disease and pulmonary hypertension. Cases of ventricular septal defect showed an appreciable increase in muscularity of both preacinar and intra-acinar (respiratory unit) arteries, and in...

An analysis is presented of the incidence of congenital heart disease among 21810 live births at the Queen Victoria Maternity Hospital, Johannesburg, over the 5-year period 1966 1970. Cases discovered before discharge from hospital, as well as those subsequently detected when attending the Transvaal Memorial Hospital for Children, are included. There were 141 children with congenital heart dise...

Atrial septal defect (ASD) is one of the most common congenital cardiac diseases [1]. ASD accounts for 7-10% of all congenital heart diseases in children and 30-33% in adults. Although ASD usually asymptomatic, it can lead to exercise intolerance, atrial arrhythmia, right ventricular dysfunction, and pulmonary arterial hypertension. Guidelines recommend closure of ASD if right ventricular enlar...

BACKGROUND Loss-of-function mutations in CHD7 cause Coloboma, Heart Disease, Atresia of Choanae, Retardation of Growth and/or Development, Genital Hypoplasia, and Ear Abnormalities With or Without Deafness (CHARGE) syndrome, a variable combination of multiple congenital malformations including heart defects. Heart defects are reported in 70% to 92% of patients with a CHD7 mutation, but most stu...