Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely unknown. We have explored the global methylation profile of fetal heart DNA in comparison to blood DNA from control subjects: an absolute correlation with the type...

BACKGROUND Congenital pulmonary airway malformation (CPAM) is a relatively rare congenital anomaly with a wide spectrum of ultrasound features depending on the specific variety of CPAM. Antenatal ultrasound is a valuable, safe, nonionizing, cost-effective, widely available and easily reproducible imaging tool and is indispensable in the diagnosis of CPAM. In this paper, we aimed to report an at...

dandy-walker syndrome is a congenital brain malformation involving the cerebellum and the fourth ventricle. the key features of this syndrome are mental retardation, cerebellar ataxia, and symptoms related to hydrocephaly. the psychiatric aspects of this syndrome have been insufficiently appreciated. described here is a 17- year- old girl with an acute manic episode emerged in the course of dan...

OBJECTIVE To study the risk for congenital anomalies in the first child of women after bariatric surgery compared with all other women giving birth to their first child and divided by maternal body mass index (BMI) groups. DESIGN Prospective, population-based register study. SETTING Sweden. SAMPLE All firstborn children to women born 1973-83 were studied to determine if they had a congeni...

Dandy-Walker Malformation (DWM) is a rare congenital malformation of the brain. It is characterized by cystic enlargement of the fourth ventricle which is communicating with an enlarged posterior fossa, cerebellar dysgenesis, high tentorial insertion and hydrocephalus. Neurocutaneous Melanosis (NCM) is a congenital neurocutaneous syndrome characterized by large or multiple melanocytic nevi and ...