Endothelin-1 (ET-1), as the most potent endothelium dependent vasoconstrictor peptide, contributes to vasoconstriction, decreased ventricular function, and volume retention in congestive heart failure (CHF). Plasma ET-1 concentrations are raised in patients with CHF, correlate with symptoms and with the haemodynamic severity, and are associated with an adverse prognosis. Endothelin receptor ant...

Congestive heart failure (CHF) remains a significant cause of death and disability in industrialized countries. Projections show that the prevalence of CHF will increase 46% from 2012 to 2030, resulting in over eight million adults with CHF in the United States. While substantial advances have been achieved in the treatment of CHF over the past two decades, CHF rivals cancer as a cause of morta...

Background Congestive heart failure (CHF) in patients and experimental animals is characterized by renal retention of salt and water and a blunted natriuretic/diuretic response to atrial natriuretic peptide (ANP). Recently, we reported that chronic treatment with the PPARgagonist rosiglitazone (RGZ) improved the natriuretic and diuretic responses to extracellular fluid volume expansion in rats ...

Provoked premature ventricular contractions (PVCs) evoke, in concomitance with an early and late blood pressure fall and overshoot, an early sympathoexcitation and a later period of sympathoinhibition, respectively. The present study was designed to examine whether in healthy subjects this is the case for spontaneous PVCs. Because of their pathophysiological relevance for arrhythmogenesis, it w...

BACKGROUND AND OBJECTIVE It has been observed that in a clinical condition like hypoxemia there is an increase in the serum Uric acid level. The objective of our study was to find out the relationship between serum uric acid levels in the severity of Heart failure. METHODS We analyze 285 patients with a diagnosis of Congestive heart failure admitted in Lady Reading Hospital Peshawar from Marc...

Matsumoto, Tetsuya, Atsuyuki Wada, Takayoshi Tsutamoto, Tomoko Omura, Hiroshi Yokohama, Masato Ohnishi, Ichiro Nakae, Masayuki Takahashi, and Masahiko Kinoshita. Vasorelaxing effects of atrial and brain natriuretic peptides on coronary circulation in heart failure. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1935–H1942, 1999.—Natriuretic peptide (NP) receptor has been postulated to be downr...

Background Patients with rheumatoid arthritis (RA) experience an excess risk of congestive heart failure (CHF), chronic inflammation plays a pivotal role in this increased risk. Despite the growing body of research on cardiovascular (CV) disease in RA, the key pathways underlying the development of abnormalities in myocardial structure and function associated with CHF remain obscure. Cardiac ma...

Pimobendan, a calcium sensitizer and phosphodiesterase III inhibitor, has positive inotropic and vasodilatory properties. Its use in patients with naturally occurring congestive heart failure (CHF) has been studied in a number of blinded, randomized, multicenter clinical trials. It has been shown to improve quality of life, reduce heart insufficiency scores, and increase median survival times f...

E xercise and activity intolerance are the most frequent and debilitating symptoms in patients with mild and moderate congestive heart failure (CHF). Paradoxically, the severity of these symptoms correlates poorly with indexes of cardiac function such as the ejection fraction and hemodynamic measurements.1,2 This discordance has focused attention on pathophysiological changes in the periphery t...