To identify PU.1 downstream target genes, we first established PU.1-knockdown K562 (K562PU.1KD) cells expressing reduced levels of PU.1 by stably transfected PU.1 siRNAs. From microarray analysis, we found that several genes including annexin 1 were markedly induced in K562PU.1KD cells. Annexin 1 is a calcium- and phospholipid-binding protein and increased expression leads to the constitutive a...

Toll like receptor (TLR) signalling pathway plays a central role in inflammatory responses through the recognition of PAMPs and DAMPs. Toll-like 4 (TLR4) is well known for LPS gram-negative bacteria leading to production cytokines. Modulation TLR gene different tissues indicates functional importance innate immunity. The aim this study was clone characterize TLR4 evaluate its constitutive tissu...

Modeling the flow curves of materials at elevated temperatures is the first step in mathematical simulation of the hot deformation processes of them. In this work a comparative study was provided to examine the capability of three different constitutive equations in modeling the hot deformation flow curves of AZ91 magnesium alloy. For this, the Arrhenius equation with strain dependent constants...