نتایج جستجو برای: contractile functions
تعداد نتایج: 511361 فیلتر نتایج به سال:
Cytokinesis in animal cells is accomplished through constriction of an actomyosin ring [1] [2] [3], which must assemble at the correct time and place in order to ensure proper division of genetic material and organelles. Budding yeast is a useful model system for determining the biochemical pathway of contractile ring assembly. The budding yeast IQGAP-like protein, Cyk1/Iqg1p, has multiple role...
Both de novo-assembled actin filaments at the division site and existing filaments recruited by directional cortical transport contribute to contractile ring formation during cytokinesis. However, it is unknown which source is more important. Here, we show that fission yeast formin For3 is responsible for node condensation into clumps in the absence of formin Cdc12. For3 localization at the div...
Anillin interacts with microtubules and is part of the astral pathway that defines cortical domains.
Cytokinesis occurs by the ingression of an actomyosin ring that separates the cell into two daughter cells. The mitotic spindle, comprising astral and central spindle microtubules, couples contractile ring ingression with DNA segregation. Cues from the central spindle activate RhoA, the upstream regulator of the contractile ring. However, additional cues from the astral microtubules also reinfo...
The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) is essential for application to pharmaceutical testing, disease modeling, ultimately therapeutic use. Multicellular 3D-tissue platforms have improved hiPSC-CMs, but probing cardiac contractile properties remains challenging in a 3D environment, especially at depth live tissues. Usi...
The present study was undertaken to investigate the effects of aminobenzyl penicillin (AB-PC), methylchlorophenyl isoxazolyl penicillin (MCI-PC), and 6-aminopenicillanic acid (6-APA) on the contractile response of guinea-pig urinary bladder. AB-PC, MCI-PC, and 6-APA, respectively, diminished the intramural electrical stimulation-induced contractile response. AB-PC had almost no effect on the co...
LvsA is a Dictyostelium protein that is essential for cytokinesis and that is related to the mammalian beige/LYST family of proteins. To better understand the function of this novel protein family we tagged LvsA with GFP using recombination techniques. GFP-LvsA is primarily associated with the membranes of the contractile vacuole system and it also has a punctate distribution in the cytoplasm. ...
AIMS Transforming growth factor-β (TGF-β) signaling is critical for the differentiation of smooth muscle cells (SMCs) into quiescent cells expressing a full repertoire of contractile proteins. Heterozygous mutations in TGF-β receptor type II (TGFBR2) disrupt TGF-β signaling and lead to genetic conditions that predispose to thoracic aortic aneurysms and dissections (TAADs). The aim of this study...
Abstract Funding Acknowledgements Type of funding sources: None. Left atrial (LA) functional abnormalities, including LA strain (LAS) and rate (LASR) reduction, are observed in patients with left ventricular diastolic disfunction (LVDD). However, the degree reduction at different stages LVDD is not fully clarified. We aimed to assess interdependence between LAS LASR parameters grades subjects a...
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