The development of hyperthermia during prolonged exercise in humans is associated with various changes in the brain, but it is not known whether the cerebral metabolism or the global cerebral blood flow (gCBF) is affected. Eight endurance-trained subjects completed two exercise bouts on a cycle ergometer. The gCBF and cerebral metabolic rates of oxygen, glucose, and lactate were determined with...

BACKGROUND The purpose of this study is to investigate whether changes could be detected in dynamic contrast-enhanced (DCE) and intra-voxel incoherent motion (IVIM) MR parameters upon MR-guided high-intensity focused ultrasound (MR-HIFU)-induced hyperthermia in a rabbit Vx2 tumor model. METHODS Five Vx2 tumor-bearing New Zealand white rabbits were treated with hyperthermia using a clinical MR...

The present study aimed to observe the effect of the biological functions of integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) Tca8113 cells and, combined with hyperthermia, several experimental methods were used to detect their biological behavi...

Hyperthermia is a proven clinical anti-cancer treatment, used in combination with radiotherapy and/or chemotherapy. During hyperthermia, tumour tissue heated to 40-43 °C using radiofrequency or microwave antennas, which strongly enhances effectiveness of and treatment quality depends on temperatures achieved planning (i.e., simulation optimization absorbed power temperature distributions) could...

BACKGROUND Hyperthermia is considered one of the new therapeutic modalities for cancer treatment and is based on the difference in thermal sensitivity between healthy tissues and tumors. During hyperthermia treatment, the temperature of the tumor is raised to 40-45°C for a definite period resulting in the destruction of cancer cells. This paper investigates design, modeling and simulation of a ...

Cellular radiosensitivity, assessed by loss of clonogenicity, has been shown to correlate with the number of radiation-induced chromosomal aberrations. Also an increased radiosensitivity by hyperthermia has been shown to correlate with an increase in chromosomal aberrations. Therefore, determination of the number of chromosomal aberrations might be used as an assay to predict the radiosensitivi...

BACKGROUND AND PURPOSE Temperature is a well-known modulator of experimental cerebral injury. We hypothesized that hyperthermia would be associated with a worsened cognitive outcome after coronary artery bypass graft surgery (CABG). METHODS Three hundred consenting patients undergoing cardiopulmonary bypass for CABG had hourly postoperative temperatures recorded. The degree of postoperative h...

OBJECTIVES Current knowledge about the incidence and risk factors for exertional hyperthermia (core body temperature ≥40°C) is predominantly based on military populations or small-sized studies in athletes. We assessed the incidence of exertional hyperthermia in 227 participants of a 15-km running race, and identified predictors for exertional hyperthermia. DESIGN Observational study. METHO...