Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease manifestations include a wide spectrum of liver pathologies as well as neurological and psychiatric abnormalities. A...

Biliary excretion is the major elimination route of copper, therefore increased hepatic copper concentrations could be caused by cholestasis. Hepatic copper accumulation is cytotoxic and results in fibrosis in hepatic tissues. Aim: The aim of this work is to determine the concentration of copper in serum and hepatic tissue in infants with cholestasis and its impact on liver function tests. Subj...

Zinc therapy has replaced penicillamine as first-line therapy for Wilson's disease. New guidelines reflect the paradigm shift in treatment that has occurred in recent years. In the old paradigm, Wilson's disease was seen as genetic disorder associated with the accumulation of copper in the liver and in other organs once the liver had become overloaded with copper. When left untreated, the disea...

Recently, iron deficiency has been connected with a heterogeneous accumulation of manganese in the rat brain. The striatum is particularly vulnerable, for there is a significant negative correlation between accumulated manganese and gamma-aminobutyric acid levels. The effect of dietary iron deficiency on the distribution of zinc and copper, two other divalent metals with essential neurobiologic...

this article present the result from a study of two sediment cores collected from theenvironmentally distinct zones of ces. accumulation status of five toxic metals: cadmium (cd), chromium(cr), cobalt (co), copper (cu) and lead (pb) were analyzed. besides texture and chns were determined tounderstand the composition of the sediment. enrichment factor (ef) and anthropogenic factor (af) wereused ...

A large number of sediment samples representing most of the active mud accumulation areas of the Gulf of Finland were studied for total cadmium, chromium, lead, mercury, arsenic, copper and zinc. The highest concentrations of metals were found in sediment surfaces in the easternmost part of the Gulf, which is influenced by the inflow of the Neva river and the loads of the city of St. Petersburg...

Copper is one of the oldest known metals used by humans. It was discovered around 9000 BC, and was first used to make metal tools and weapons. Medical applications of copper were known to the ancient Egyptians and Greeks. The metal has widespread and varied uses in modern society. Thus copper has played an important part in human cultural evolution, but the element has a much more ancient role ...

Wilson's disease (WD) is an autosomal recessive disorder that results in accumulation of copper in the liver as a consequence of mutations in the gene encoding the copper-transporting P-type ATPase (ATP7B). WD is a chronic liver disorder, and individuals with the disease present with a variety of complications, including steatosis, cholestasis, cirrhosis, and liver failure. Similar to patients ...

We surveyed histochemically detectable copper in various liver diseases with emphasis on chronic biliary disease (CBD) and venous outflow impairment. Using rhodanine, we graded copper accumulation in 298 liver specimens: venous outflow impairment (n = 64), CBD (n = 123), Wilson disease (WD) (n = 12), chronic hepatitis C (n = 32), steatohepatitis (n = 28), sarcoidosis (n = 15), cholestatic hepat...