Selection of a suitable graft for allogeneic hematopoietic stem cell transplantation involves consideration of both donor and recipient characteristics. Of primary importance is sufficient donor-recipient HLA matching to ensure engraftment and acceptable rates of GVHD. In this Perspective, the National Marrow Donor Program and the Center for International Blood and Marrow Transplant Research pr...

Stem cells play important role in the development and in the maintenance of specific tissues. They have been identified in majority of the organs like liver, blood, skin and intestine. Role of stem cells in regenerative medicine have been implicated in many chronic diseases. Stem cell research is a new opportunity to those patients whose organs are damaged or diseased. The discovery of stem cel...

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...

Despite the fact that a number of therapeutic modalities have shown promise in treatment spinal cord injury (SCI), focusing solely on one aspect recovery will not lead to successful and useful regeneration people. The current study targets an integrated approach neuroprotection rehabilitation strategies treat injury, increasing nerve functional through sensorimotor training cell transplantation...

Background: Spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. Transplantation of Schwann cells has shown a great promising result for spinal cord injury (SCI). However, harvesting Schwann cell has been limited due to donor morbidity and limited expansion capacity. Furthermore, accessible sources such as bone marrow stem cells ...

introduction: allogeneic hematopoietic stem cell transplantation is a potentially curative treatment modality for hematological malignancies. we evaluated the outcome of patients suffering from hematological malignancies, including acute leukemias, chronic myeloid leukemia and myelodysplastic syndrome after allogeneic transplantation. methods: all patients having hematological malignancies with...

GlobalUseof Peripheral BloodvsBoneMarrow as Sourceof StemCells forAllogeneic Transplantation inPatientsWithBoneMarrowFailure Hematopoietic stemcell transplantation (HSCT) is a therapeutic option formany patients with bonemarrow failure.1 Bone marrowwas initially the only stem cell source available until the 1990swhen peripheral blood stem cells (PBSCs) and cord blood began to be used. Currently...

Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertai...

Abstract Background iPSC (induced pluripotent stem cells) banks of lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation derived cell therapies. Cord blood offer extensive source HLA-typed cells suitable for reprogramming iPSC. Several initiatives worldwide have been undertaken create na...

objectives: the study of erythropoiesis needs to develop the methods for erythroid progenitor cells (epcs) culture using stem cell potency to differentiate into variety of hematopoietic cells lineages. in this study, we induced differentiation of cord blood stem cells into erythroid progenitor cells in a semisolid culture media. materials and methods: cord blood mononuclear cells were isolate...