Introduction: Triple immunohistochemical (IHC) stains including antibodies specific for alphamethylacyl-CoA-racemase and basal cell markers have been a valuable aid in accurate identification of prostate carcinoma. However, accurate quantification of minuscule areas of prostate carcinoma in biopsy specimens can often be a challenge. Here we assessed the diagnostic value and quantitative use of ...

Angiosarcomas are endothelial cell neoplasms in the lining of the blood vessel wall and account for about 0.04% of all breast malignancies with a high rate of error in primary diagnosis. The breast angiosarcoma is a rare and uncommon pathology and has been described mostly as case reports. Indeed, only a limited number of cases have been published. Accordingly, the natural history of this tumor...

Endoscopic ultrasound (EUS) enables a gastroenterologist to sample the masses of the middle and inferior mediastinum, which are adjacent to the esophagus; cystic or solid lesions of the pancreas, which are adjacent to the stomach and duodenum; and perirectal lesions. Needles used for EUS sampling include aspiration (19, 20, and 22 Gauge) or core biopsy needles (ProCore and Trucut) (19, 20, and ...

Core needle biopsy (CNB) was introduced as an alternative diagnostic tool to fine-needle aspiration (FNA), and is increasingly being used in the preoperative assessment of thyroid nodules. CNB provides a definitive diagnosis in most cases, but it sometimes may be inconclusive. CNB has the advantage of enabling a histologic examination in relation to the surrounding thyroid tissue, immunohistoch...

non-hodgkin lymphoma usually presents with generalized lymphadenopathy, but it can also involve any part of the human body. lymphomatous involvement of muscles is a rare presentation and has been reported to occur in only 1.1% in non-hodgkin lymphoma. here we, present a 32 year-old iranian man with primary involvement of spleen, bone, bone marrow and muscle, mimicking soft tissue sarcoma; core ...

Needle-based procedures, such as biopsy, thermal ablation, brachytherapy, and drug delivery, provide a minimally invasive means for diagnosis or treatment. The success of the procedure relies on the needle reaching the physician’s desired target (typically identified on a medical image) accurately. However, due to tissue deformation and the accuracy limits of human hand–eye coordination, the ne...

PURPOSE To compare the effectiveness of fine needle aspiration cytology (FNAC) with core biopsy (CB) in the pre-operative diagnosis of radial scar (RS) of the breast. PATIENTS AND METHODS A retrospective analysis was made of all radial scars diagnosed on surgical histology over an 8-year period. Comparison was made between the results of different preoperative needle biopsy techniques and sur...

The optimum technique for histological confirmation of the nature of a parotid mass remains controversial. Fine needle aspiration cytology (FNAC), which has traditionally been used, is associated with high non-diagnostic and false negative rates, and ultrasound (US)-guided core biopsy and frozen section have been explored as alternatives. US-guided core biopsy is more invasive than FNAC, but is...

BACKGROUND The number of core biopsies done for breast abnormalities is increasing. The risk of skin seeding resulting from core biopsy is unknown. METHODS Consecutive patients diagnosed with breast cancer were studied. The skin and subcutaneous fat surrounding the site of core needle penetration were excised and studied by routine histologic staining. Findings were correlated with other clin...

Giant multilocular prostatic cystadenomas are rare tumors (only 20 cases reported so far) that may present as large abdominal masses causing symptoms of urinary frequency and urgency. Routine needle core biopsy can be misleading and reveals only benign prostatic tissue. We report the case of a 61-year-old male who presented with a large abdomino-pelvic mass and symptoms of an enlarged prostate....