AIMS To evaluate the efficacy of amniotic membrane transplantation (AMT) for ocular surface reconstruction. METHODS 10 consecutive patients who underwent AMT were included. The indications were: group A, cases with persistent epithelial defect after corneal abscess (n = 1), radiation (n = 1), or chemical burn (n = 3); group B, cases with epithelial defect and severe stromal thinning and impen...

A double-masked study of the effects of topical ascorbate on alkali burns utilized 37 rabbit eyes subjected to 20 sec, 12 mm, IN sodium hydroxide burns. Preliminary studies established the ocular acceptability, penetrability, and stability of the solutions used. Eighteen eyes in the experimental group were given two drops of10% ascorbate in Adsorbotear vehicle hourly for 14 hr of each day. Nine...

purpose: to report the histopathological diagnoses of recipient corneal buttons in patients undergoing penetrating keratoplasty. methods: in this observational case series, all recipient corneal specimens sent to the ophthalmic pathology laboratory of the eye bank of iran between 2004 and 2007 underwent histopathologic examination. results: overall, 315 corneal specimens were evaluated. histopa...

Serial sections prepared from biopsies of the deep tarsal portion of the inferior nasal conjunctival fornix in normal subjects and in patients with various dry eye syndromes were analyzed with respect to the goblet cell densities. When compared to normal subjects, individuals with keratitis sicca, Stevens-Johnson syndrome, ocular pemphigoid, and acute alkali burn all demonstrated progressively ...

4-Biphenylacetic acid (BPAA),a prostaglandin-synthesis inhibitor, was tested for its effects on prostaglandin-related, laboratory models of ocular inflammation. Topically applied, BPAA inhibited arachidonic acid, but not prostaglandin E-induced increases in rabbit intraocular pressure (IOP). BPAA inhibited the IOP response to alkali burn and altered IOP changes following paracentesis. In vitro,...

The neutrophilic response in the alkali-injured rabbit cornea can be separated into two peaks: the first from 12-24 hr and the second at 21 days. In the experiments detailed here, alkali-injured rabbit eyes were treated for 0-7 days (early peak), 6-35 days (late peak), or 0-35 days (both peaks) with 6.5% or 10% topical citrate. Clinical evaluation of these eyes showed that treatment with 10% ci...