Stimulation protocols for medical devices should be rationally designed. For episodic migraine with aura we outline model-based design strategies toward preventive and acute therapies using stereotactic cortical neuromodulation. To this end, we regard a localized spreading depression (SD) wave segment as a central element in migraine pathophysiology. To describe nucleation and propagation featu...

Fitts' law describes the fundamental trade-off between movement accuracy and speed: it states that the duration of reaching movements is a function of target size (TS) and distance. While Fitts' law has been extensively studied in ergonomics and has guided the design of human-computer interfaces, there have been few studies on its neuronal correlates. To elucidate sensorimotor cortical activity...

this study was aimed to investigate the use of panoramic radiography in patients with low bone mineral density (bmd) in order to diagnose and prevent osteoporotic fractures. panoramic radiographs of 60 patients  (20 men and 40 women) aged from 40 to 70 years with cortical thicknesses of less than 3 mm in the mandibular angle were selected from patients referred to a dentomaxillofacial radiology...

Long-term effects of prenatal hypoxia on embryonic days E14 or E18 on the number, type and localization of cortical neurons, density of labile synaptopodin-positive dendritic spines, and parietal cortex-dependent behavioral tasks were examined in the postnatal ontogenesis of rats. An injection of 5'ethynyl-2'deoxyuridine to pregnant rats was used to label neurons generated on E14 or E18 in the ...

Four critically ill patients developed phenytoin toxicity. Hypoalbuminemia or concomitant displacing drugs resulted in an increased fraction of unbound drug. Clinical findings included gradual decrease in level of consciousness and cerebellar signs. Marked phenytoin toxicity can occur in critically ill patients with hypoalbuminemia and can often be detected only by direct measurement of free ph...

Cerebellar toxicity is a known potential adverse effect of high-dose cytarabine chemotherapy. Oncology nurses are expected to assess patients receiving high-dose cytarabine for cerebellar toxicity prior to administering each dose. Information regarding cerebellar assessment techniques and documentation of findings is limited in the nursing literature. This article provides nurses with a standar...

BACKGROUND While mammalian cortical granules are important in fertilization, their biochemical composition and functions are not fully understood. We previously showed that the ABL2 antibody, made against zona free mouse blastocysts, binds to a 75-kDa cortical granule protein (p75) present in a subpopulation of mouse cortical granules. The purpose of this study was to identify and characterize ...

PURPOSE The aim of this study was to examine whether glutathione S-transferase (GST) polymorphisms were associated with a susceptibility to age-related cortical cataract (cortical ARC) in the Han Chinese population. METHODS Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) gene polymorphisms were genotyped in 422 Han Chinese patients with age-related cortical catar...

Cortical blindness is defined as bilateral visual loss due to disruption of the pathways beyond lateral geniculate body. Visual disturbance a result cortical lesion can manifest in different ways. Anton's syndrome one manifestations blindness, which presents denial vision associated with confabulation setting obvious loss. This case illustrates challenges diagnosing emergency setting.