BACKGROUND Experimental studies have demonstrated that angiotensin II (ANG-II)-induced oxidative stress contributes to the pathogenesis of I/R injury. OBJECTIVES This study was aimed to investigate the protective effects of co-administration of losartan, as a selective ANG-II type 1 receptor (AT1R) blocker, and vanillic acid (VA), as an antioxidant, in I/R-induced oxidative stress in isolated...

Schanzel H., E. Hegerova, B. Koudela, V. Lohr: Activity of Creatine-Phosphokinase in the Course of Experimental Trichinellosis. Acta vet. Brno, 47, 1978: 91-95. Activity of serum cteatine-phosphokinase has been determined at different intervals after experimental infestation of mice and guinea pigs by larvae of Trichinella spiralis. Blood samples were treated by Bio-La-test kreatinkinaza Lachem...

BACKGROUND Deep oceans have been suggested as a possible site where the origin of life occurred. Along with this theoretical lineage, experiments using components from deep ocean water to recreate life is underway. Here, we propose that if terrestrial organisms indeed evolved from deep oceans, supply of deep ocean mineral water (DOM) to humans, as a land creature, may replenish loss of molecula...

The aim of this investigation was to study the antidiabetic impact of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in repressing diabetes induced cardio-myopathy in diabetic rats. Type 2 diabetes was promoted in rats by a single intraperitoneal injection of streptozotocin (30mg/kg body wight). C. flexuosus and P. dactylifera extracts (200mg/...

PURPOSE This study was conducted to evaluate the effects of ischemic preconditioning (IP) with a short period of reperfusion (2 min) during brief ischemic preconditioning (6 min) on patients undergoing coronary artery bypass grafting (CABG). METHODS In a randomized controlled trial, 40 patients undergoing on-pump CABG with cold blood cardioplegia were allocated into two groups, one IP and one...

We evaluated scintigraphic techniques in estimating infarct size. In 26 patients with acute transmural myocardial infarction, 99mTechnetium pyrophosphate (TcPYP) infarct scintigraphy, gated cardiac blood pool scintigraphy and 201-Thallium (201-Tl) perfusion scintigraphy were performed. Invasive hemodynamic measurements were obtained and serial venous blood specimens taken for measurement of tot...

Percutaneous coronary intervention (PCI) has become the predominant procedure for coronary revascularization in patients with both stable and unstable coronary artery disease (CAD). Over the past two decades, technical advances in PCI have resulted in a better and safer therapeutic procedure with minimal procedural complications. However, about 30% of patients undergoing elective PCI sustain my...

Oxidative stress is the main factor in Doxorubicin (DOX) induced cardiotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or Solanum torvum extract (100 mg/kg and 300 mg/kg, p.o.) prior to DOX or S. torvum (100 mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Cardiotoxicity was assessed by recording changes in ECG, heart rate and measuring the levels of c...

BACKGROUND Pro- and anti-inflammatory cytokines play a major role in the development of acute myocardial infarction (AMI). This paper tests the hypothesis that atorvastatin may attenuate the severity of myocardial ischemic injury by restoring the balance between pro-inflammatory and anti-inflammatory mediators. MATERIALS AND METHODS Sixty adult male albino rats were used. Experimental AMI was...