BACKGROUND Creatine is widely used as an ergogenic substance among athletes. Safety of prolonged creatine intake has been questioned, based upon case reports and animal data. We investigated the effect of prolonged creatine ingestion on renal function in animals with normal kidney function or pre-existing kidney failure, respectively. METHODS Male Wistar rats were randomly allocated to four e...

Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand. The aim of the present book was to outline our current understanding on many of these links. In this chapter, we summarize the main messages and conclusions presented in this book. In ...

AIMS Studies on the glycoprotein IIb-IIIa receptor blocker abciximab in patients undergoing percutaneous coronary intervention consistently show a reduction in procedure-related myocardial infarction. Some such infarcts are characterized by elevated creatine kinase or creatine kinase-MB, without apparent clinical symptoms. The clinical relevance of such 'creatine kinase leaks' has been question...

the aim of this study was to determine the effect of creatine supplementation on sprint and skill performance in young soccer players. seventeen young soccer players (mean age: 17.18 ± 1.37 y, mean high: 169.6 ± 6.17 cm and mean weight: 61.67 ± 1.37 kg) participated in this study. subjects were assigned to either a creatine (5 g of cr, 4 times per day for 7 days) or a placebo group (same dosage...

Background It has been well-established that creatine monohydrate (CrM) increases whole body creatine retention and muscle creatine content. Extracts of Russian Tarragon (RT) have been reported to produce anti-hyperglycemic effects [1] and influence plasma creatine levels during the ingestion of CrM [2]. Theoretically, RT ingestion with CrM may promote greater creatine retention than ingesting ...

Background Oral creatine supplementation is known to provide numerous benefits, including increases in lean muscle mass, muscular strength, and enhanced performance in various athletic capacities. The creatine transporter is a transmembrane protein that mediates the entry of creatine from the circulation into the muscle cell. Little is understood about the importance of the creatine transporter...

In recent years, the practice of bodybuilding has seen an increase in number fans gyms and, along with this increase, use dietary supplements, such as creatine and whey protein, been growing considerably by practitioners sport. addition, daily protein intake bodybuilders exceeds maximum recommendation, which, together these can lead to kidney and/or liver failure. The objective study was analyz...