Introduction Eosinophilic gastroenteritis is an uncommon disease characterized by peripheral eosinophilia and eosinophilic infiltration of the gastrointestinal tract. The bone marrow shows a reactive eosinophilia and the symptoms and signs usually reflect the layer of bowel which is most severely affected. Predominant mucosal disease may be associated with malabsorption, muscle disease with obs...

A patient with a 15 year history of diarrhoea of unknown origin is described. Scintigraphy with technetium-99m labelled albumin suggested albumin loss at the terminal ileum and caecum; subsequent colonoscopic biopsies of these macroscopically normal looking areas showed abundant infiltration with eosinophils. A diagnosis of eosinophilic enterocolitis was made. Treatment with prednisolone had go...

Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca2+ in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mg2+, Sr2+ and Ba2+ were ...

\ 7arious drugs and methods have been used in the * treatment of asthma in Japan. The basic treatment in Japan is presumably similar to other countries. For symptomatic treatment, bronchodilators which include (J-agonists and xanthine derivatives, are considered to be the first choice drugs. Steroids are used for intractable or life-threatening asthma. Other medications include anticough prepar...

Anaphylaxis induced by exercise after the intake of certain foods is referred to as food-dependent exercise-induced anaphylaxis (FDEIA). Only the preventive medication such as oral sodium cromoglycate and oral combined cetirizine-montelukast was tried in FDEIA. Specific oral tolerance induction (SOTI) using IFN-gamma was tried in 2 cases of FDEIA for wheat. Merely, exercise accompanied every tr...

The anti-allergic cromones were originally synthesized in the 1960s by Fisons Plc, and the first drug to emerge from this program, disodium cromoglycate was subsequently marketed for the treatment of asthma and other allergic conditions. Whilst early studies demonstrated that the ability of the cromones to prevent allergic reactions was due to their 'mast cell stabilizing' properties, the exact...

The activity of cyclic AMP-dependent protein kinase (protein kinase A) in the sensitized rat mast cell was decreased 2 min after antigen challenge when the histamine release exhibited a maximum. Drugs inhibiting allergic mediator release such as disodium cromoglycate, tranilast and theophylline significantly inhibited antigen-induced histamine release and reduced a decrease in the activity of p...

A CHEAPER PREPARATION OF DISODIUM CROMOGLYCATE IN THE TREATMENT OF ALLERGIC RHINITIS From Major N K Cooper FRCS(Ed), DLO, RAMC Sir, The clinical symptoms of allergic rhinitis are brought on in predisposed individuals during the pollen season by the release of histamine from mast cells in the nasal mucosal,2 following the combination of antigen with antibody at the surface of these cells• This p...