Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a specific humoral growth factor that stimulates both neutrophilic granulocyte and macrophage production by bone marrow hematopoietic progenitor cells. GM-CSF also stimulates the proliferation and clonal growth of both tissue macrophages and blood monocytes. Although at low concentrations GM-CSF was unable to support the long-term gro...

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is used to counter chemotherapy-induced neutropenia. Our previous study showed an inverse correlation between serum rhG-CSF levels and the number of circulating neutrophils in cancer patients (H. Takatani, H. Soda, M. Fukuda, M. Watanabe, A. Kinoshita, T. Nakamura, and M. Oka, Antimicrob. Agents Chemother. 40:988-991, 1996). The ...

vaccines against the hiv-1 virus offers the best hope for eliminating hiv-associated mortality. recombinant adenovector type 5 (rad5) vaccine is a potential candidate for preventive vaccine strategies. in this study, we evaluated the rad5 prime/protein boost strategy in a murine model. we used rad5 harboring single hiv-1 genes. these genes, including gag (p24) and exon1 of tat, were amplified f...

background and objectives: febrile convulsion is a common disorder in children. viral infections such as human herpes virus 6 (hhv-6) which results in roseola infantum may contribute to developing seizure. the objective of this study was to determine the prevalence of hhv-6 by detecting dna in cerebrospinal fluid (csf) of children with febrile convulsion and without any rash of roseola infantum...

this article describes a knowledge management (km) success model that is derived from observations generated through an empirical study of km in an iranian consultant company and km success factors in the literature which is shown that company has a weak situation in each factor. so company needs a measurement model in order to assess knowledge management implementation processes in each step t...

background & aim: spinal cord injury (sci) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities.  methods & materials/patients: in this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (g-csf) and...

background: survival of colorectal cancer (crc) patients is considerably stage-dependent therefore, early diagnosis is a pivotal factor in decreasing mortality and morbidity associated with this cancer. gm-csf and il-7 are reported to increase in different cancers and we aim to investigate the pre-treatment serum levels of gm-csf and il-7 in iranian patients with colorectal cancer. methods: 127...

Background: Bacteremia is relatively common in children with urinary tract infection (UTI). The aim of the present study was to determine the frequency of bacterial meningitis among neonates with laboratory-confirmed UTI.Methods: This retrospective cross-sectional study was performed on 163 hospitalized neonates in Ali Asghar and Shahid Akbarabadi hospitals affiliated to Iran University o...

conclusion clinical manifestations and csf abnormality of neurobrucellosis is similar to tuberculosis and neurobrucellosis must be kept in mind in approach of patients with acute or chronic lymphocytic meningitis with increased protein and low glucose level in csf and risk factors of brucellosis. results neurological manifestations include meningitis (64.9%), meningoencephalitis (11.6%), crania...