We appreciate the interest of Nastro et al. in our recent article (1); their comments (2) offer an opportunity to discuss the work further. Our study was undertaken with a collection of Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates for which colistin (Cst) MICs were elevated. It was observed that among the commercial methods for Cst susceptibility testing (ST), gradient di...

BACKGROUND Brain imaging has shown that not only the cortico-spinal tract (CST), but also alternate corticofugal motor fibers (aMF), such as the cortico-rubro-spinal and cortico-reticulo-spinal tract, influence residual motor output after stroke. So far, studies mainly have investigated each tract separately. A combined analysis of CST and aMF with assessment of their interactive role, i.e., th...

The telomere-ending binding protein complex CST (Cdc13-Stn1-Ten1) mediates critical functions in both telomere protection and replication. We devised a co-expression and affinity purification strategy for isolating large quantities of the complete Candida glabrata CST complex. The complex was found to exhibit a 2∶4∶2 or 2∶6∶2 stoichiometry as judged by the ratio of the subunits and the native s...

Competency to stand trial (CST) has been among the most thoroughly researched psycholegal issues in the past 20 years. However, little attention has been given to CST in juveniles facing delinquency or criminal proceedings. In a sample of 112 pretrial juvenile defendants undergoing court-ordered CST evaluations, 14 percent of the sample was judged incompetent to stand trial (IST). Sixty-one (55...

We used transcranial magnetic stimulation (TMS) to clarify how non-verbal emotionally-characterized sounds modulate the excitability of the corticospinal motor tract (CST). While subjects were listening to sounds (monaurally and binaurally), single TMS pulses were delivered to either left or right primary motor cortex (M1), and electromyographic activities were recorded from the contralateral a...

Understanding the intra- and extracellular proteins involved in the development of the corticospinal tract (CST) may offer insights into how the pathway could be regenerated following traumatic spinal cord injury. Currently, however, little is known about the proteome of the developing corticospinal system. The present study, therefore, has used quantitative proteomics and bioinformatics to det...

Diffusion tensor tractography (DTT) is useful for exploring the state of the corticospinal tract (CST). An accurate estimation of the integrity of the CST in the early stage of a cerebral infarct would enable a determination of motor recovery. DTT was performed to classify CST integrity following a corona radiata infarct to evaluate if the procedure could characterize the motor outcome of the a...

BACKGROUND AND PURPOSE Motor recovery after stroke has been shown to be correlated with both the fractional anisotropy (FA) of the affected corticospinal tract (CST) and the interhemispheric resting-state functional connectivity (rsFC) of the primary motor cortex (M1). However, the role of the restoration or enhancement of the M1-M1 rsFC in motor recovery remains largely unknown. We aimed to cl...

Context: Core strength training (CST) has been popular in the fitness industry for a decade. Although strong core muscles are believed to enhance athletic performance, only few scientific studies have been conducted to identify the effectiveness of CST on improving athletic performance. Objective: Identify the effects of a 6-wk CST on running kinetics, lower extremity stability, and running per...

We appreciate the interest of Nastro et al. in our recent article (1); their comments (2) offer an opportunity to discuss the work further. Our study was undertaken with a collection of Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates for which colistin (Cst) MICs were elevated. It was observed that among the commercial methods for Cst susceptibility testing (ST), gradient di...