Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of TNF family, is an interesting ligand which selectively induces apoptosis in tumor cells and, therefore, it has been developed for cancer therapy. This ligand has been produced by various hosts such as E.coli. However, protein expression in E.coli cytoplasm leads to problems such as incorrect folding, reduction in biolo...

Three cis-chelating di-N-heterocyclic carbene palladium(II) complexes [Pd(X)2(di- NHC)] (X= tsac, sac and bit) tsac= thiosaccharinate, sac= saccharinate, bit= benzisothiazolinate, bearing different anionic co-ligand was synthesized characterized. A series of (2-5) homo-dicarbene ligand with varying propylene-bridged (C3) N-heterocyclic backbones (imidazole) have been by reaction [Pd(OAc)2] the ...

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates range functional groups advances field diene hydrofunctionalization.

The factors determining the catalytic performance of a recently discovered system for direct intermolecular alkyne hydroarylations, comprising gold(I) complex general formula LAuX (L = neutral ligand; X weakly coordinating counteranion) and an ionic liquid as solvent, have been investigated. In particular, effect anion, cation, electronic steric properties ligand L considered. results investiga...

The synthesis of a new tridentate Schiff-base thiosemicarbazone ligand (HL) that derived from the reaction ((R)-2-((4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-di methyl- cyclohexane-1,3-dione with thiosemicarbazide is reported. title ligand(E)-2-((R)-2-((R)-(4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-dimethyl-3-oxocyclohexylidene)hydrazine-1-carbothioamide selected...