She was there for her flu shot. She was planning on going on a cruise. But of course we also spoke about her Cushing disease, about the side effects and the treatment. It was a memorable encounter, but I hadn’t realized what an impression Mrs B. had made until I encountered a problem-based learning case in the endocrinology portion of my second-year curriculum. While completing the case, I real...

Abstract Carney Complex (CNC) is a rare multiple endocrine syndrome dueto PRKR1A germline mutations. Primary pigmented nodular adrenal disease (PPNAD), the most frequent manifestation of responsible for non-ACTH dependent Cushing and bilateral adrenalectomy recommended treatment. We had followed up CNC family with mainly secondary to PPNAD more than 40 years over 2 generations. Six members carr...