A discouraging conclusion to many years of study of the natural history of sarcoidosis is the realization that the proper word for the course of sarcoidosis is 'unpredictable'. An impressive lesson of a controlled study was the frequency with which unexpected and dramatic improvement occurred in the placebo group. Although patients with pulmonary infiltration, uveitis and cutaneous sarcoid have...

BACKGROUND Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases. CASE PRESENTATION A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/...

BACKGROUND Pediatric sarcoidosis has traditionally been divided into 2 distinct groups: (1) school-aged children and adolescents with frequent involvement of the lungs and mediastinal lymph nodes (similar to adult sarcoidosis) and (2) infants and preschoolers with the triad of arthritis, uveitis, and a cutaneous eruption of discrete small papules, referred to as early-onset sarcoidosis. Blau sy...

Sarcoidosis is a granulomatous disease that can present systemically, but primarily has pulmonary manifestations. It is reported across all races, but has a higher incidence among African Americans. Neurological involvement in sarcoidosis is rare, with cranial nerve seven being the most commonly reported neurological finding. Trigeminal neuralgia, as presented in this case, is very rare. A 38-y...

Sarcoidosis is a multisystem inflammatory disease of unknown etiology, characterized by noncaseating epithelioid cell granulomas. In sarcoidosis, the most common radiological findings are mediastinal and bilateral hilar lymph node enlargement. We present a case of sarcoidosis with a rare radiological aspect of pulmonary hilar tumor mass.A 54-year-old female patient, active smoker (40 packs/year...

Sarcoidosis, a multisystem granulomatous disorder of unknown etiology, is characterized by depression of cutaneous delayed-type hypersensitivity and a heightened helper T cell type 1 immune response in the affected organs.1 Sarcoidosis occurs worldwide and affects young and middle-age adults of both sexes. Many patients remain asymptomatic, and spontaneous remission is common. Sarcoidosis usual...

The patient, a 46-year-old black woman, was referred to the dermatology clinic at Washington University, St Louis, Mo, for evaluation of reddish-purple nodules on her face and shins. The patient’s medical history was significant for hypothyroidism and an arrhythmia. Findings from a punch biopsy from her right nasal ala showed confluent granulomas with central caseous necrosis in the dermis. Fin...

In 1941, Kveim (1) described the production of a cutaneous reaction in patients with sarcoidosis following the intracutaneous injection of heated saline suspensions of lymph glands obtained from active cases of that disease. The response, consisting of a small, brownish-red, indurated papule at the site of injection was remarkable for its slow evolution and its persistence. Characteristically, ...

ocular involvement is seen in approximately 25% of patients with sarcoidosis. uveitis is the most common ocular manifestation, but sarcoidosis may involve any part of the eye. orbital manifestations of sarcoidosis are uncommon with few series in the literature. a 65-year-old woman presented with redness of the right eye and painless, unilateral eyelid swelling. orbital scanning revealed mass in...

Granulomatous disorders include a wide variety of infectious and non-infectious conditions with heterogeneous clinical courses considerable constraints affected organs. We take cutaneous sarcoidosis as model disease to acquire new insights into the pathomechanisms granulomas. combined single-cell high-dimensional spatial transcriptomics fluorescently labeled antibody detection for protein expre...