Cyclic AMP (o-i to 1 mM) was found to inhibit the growth of human liver cells in monolayer cultures. Significant amounts of degradation products were not detected in the medium indicating that the growth-inhibiting effect was associated with the intact cyclic nucleotide. DNA synthesis in the liver cell cultures, as measured by thymidine incorporation into acidinsoluble material, was markedly in...

Aneurysm growth is accompanied by formation of intraluminal thrombus. The onset of thrombus rupture via unstable void growth is studied in the present note. The experimentally calibrated constitutive model of thrombus developed by Wang et al. (2001) is enhanced with a failure description and used for analysis of cavitation. It is found that unstable cavity growth can start at hydrostatic tensio...

Previous work from this laboratory indicated that the addition of cyclic adenosine 3’,5’-monophosphate (cyclic AMP) to the culture medium decreases the growth rate of E. cob. The cyclic AMP concentration necessary for growth inhibition is the same as that required for the reversal of permanent catabolite repression [ 11. On the other hand, growth inhibition was not observed in mutants defective...

Mechanical loading has been widely considered to be a crucial regulatory factor for growth plate development, but the exact mechanisms of this regulation are still not completely understood. In the growth plate, parathyroid hormone-related protein (PTHrP) regulates chondrocyte differentiation and longitudinal growth. Cyclic mechanical strain has been demonstrated to influence growth plate chond...

The OntoLex W3C Community Group has been working for more than three years on a shared lexicon model for ontologies, called lemon. The lemon model consists of a core model that is complemented by a number of modules accounting for specific aspects in the modeling of lexical information within ontologies. In many usage scenarios, the discovery and exploitation of linguistically grounded ontologi...

A lossless dielectric object situated in a lossy dielectric medium (soil) constitutes a void in a conducting background, which can be detected via an electromagnetic-induction (EMI) sensor operating at appropriate frequencies. The electromagnetic character of this void is dependent on the target and soil properties, as well as on the frequency of operation. We utilize the rigorous method of mom...

the basic structure of a reactor physics laboratory environment simulation software, developed using object modeling technique (omt), and based on the reactor point kinetic equation, is presented. also, various capabilities of the simulator in teaching the fundamental concepts of reactor physics are discussed. in this virtual laboratory, student can perform seven different experiments, namely, ...