Pioglitazone is a thiazolidinedione derivative used for the treatment of type 2 diabetes. The drug's poor aqueous solubility and slow dissolution rate are the main causes of its limited therapeutic action in some cases. The aim of the present study is to formulate a more soluble product of pioglitazone at physiological pH. The potential interaction of pioglitazone with cyclodextrins and water-s...

By simply heating mixtures of alpha-cyclodextrins and dumbbell-like poly(ethylene glycol) derivatives at 120 degrees C, polyrotaxanes form spontaneously via reversible chain exchange between acylhydrazone bonds, which have been proven by analyses of diffusion-ordered NMR, WAXD, 1H NMR, solid-state 13C CP/MAS NMR, DSC and UV-Vis together.

Cyclodextrins facilitate non-covalent fluorescence energy transfer from a variety of pesticides to high quantum-yield fluorophores, resulting in a rapid, sensitive detection scheme for these compounds with detection limits as low as two micromolar. Such a facile detection tool has significant potential applications in agriculture and public health research.

The alpha,alpha'-dibromo-o-xylylene cap has been installed at the secondary hydroxyls of a single glucopyranosyl residue in cyclodextrins in one pot and with total regioselectivity; the resulting cyclic ether acts as a removable hinge, allowing selective elaboration of the secondary face and modulating both the self-association and the inclusion capabilities of the hosts.

Cyclodextrins (CDs) are of increasing scientific and commercial interest because they are readily available, harmless and well-defined, forming sophisticated supramolecular structures in aqueous media. More than 2,300 publications and more than 1,200 patents appeared in 2015 in which CDs played a significant role. As exemplified in the following, CD chemistry has developed into a very attractiv...

Immobilization of light-driven molecular shuttles onto the surface of the silicon nanowires (SiNWs) was realized. The α-cyclodextrins as the shuttles could be reversibly translocated along the thread by the optical stimuli. Such SiNWs-based molecular shuttles also exhibited sequential logic with optical stimuli as the input and fluorescence as the output.