نتایج جستجو برای: cyp27b1
تعداد نتایج: 360 فیلتر نتایج به سال:
Recently, we demonstrated that some A-ring-modified vitamin D3 analogs had unique biological activity. Of these analogs, 2 -propoxy-1 ,25(OH)2D3 (C3O1) and 2 -(3-hydroxypropoxy)1 ,25(OH)2D3 (O2C3) were examined for metabolism by CYP27A1 and CYP24A1. Surprisingly, CYP27A1 catalyzed the conversion from C3O1 to O2C3, which has 3 times more affinity for vitamin D receptor than C3O1. Thus, the conve...
Background and Objectives: Hypertensive disorders are one of the causes of morbidity and mortality, which occur in 5% of pregnancies. One of the causes of preeclampsia, is inappropriate regulation of activator of placental Cyp27B1 enzyme, which is induced by vitamin D deficiency. This study aimed to assess the relationship between the level of vitamin D with risk of preeclampsia in pregnant wom...
Background Idiopathic inflammatory myopathies (IIM) are chronic disorders characterised, apart from extramuscular manifestations, by symmetrical progressive muscle weakness that may persist even after pharmacological suppression of inflammation, suggesting a significant involvement nonimmune mechanisms. Low levels vitamin D have been associated with several autoimmune diseases. Vitamin is essen...
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