Mitochondrial Cytochrome Oxidase Subunit I DNA sequences are a good discriminative marker for phylogenetic studies in crustaceans and especially in amphipoda. In the present study, molecular and morphological data were analyzed to test whether Gammarus lobifer authority and Gammarus balutchi authority which one or two geographically separated but morphologically similar species. The analyses pr...

subunits that always include one or more homologues of Ulrich Gohlke, Antony Warne and the mitochondrially coded eukaryotic proteins (Saraste, Matti Saraste 1990). European Molecular Biology Laboratory, Biological Structures The Gram-negative eubacterium Escherichia coli posProgramme, Meyerhofstrasse 1, Postfach 10.2209, sesses a branched respiratory chain. Depending on the D-69012 Heidelberg, ...

Cultures of mutant cni-1, a chromosomal mutant of Neurospora crassa, undergo a marked change in respiratory properties as the age of the culture increases. Early log phase cultures have a high level of respiration that is insensitive to inhibition by cyanide or antimycin A. Late log and stationary phase cultures have reduced rates of respiration. A high percentage of this respiration is inhibit...

Cytochrome oxidase from beef heart mitochondria is a 2O4 kDa large protein consisting of 13 subunits of which the numbers 1-111 are encoded by the mitochoridrial DNA, while the remaining subunits (IV-VIII) are encoded by the nuclear genome. The protein contains 2 iron heme groups (cytochrome a and cytochrome a3), 2 Cu centres (CUA and CUB) and 1 Zn atom. The heme groups and the CuB centre are l...

White, David C. (University of Kentucky College of Medicine, Lexington). Synthesis of 2-demethyl vitamin K(2) and the cytochrome system in Haemophilus. J. Bacteriol. 89:299-305. 1965.-The synthesis of the respiratory quinone, 2-demethyl vitamin K(2), is stimulated in Haemophilus parainfluenzae under conditions which provoke the synthesis of the cytochrome system. However, the various components...

There appears to be general agreement that cytochrome oxidase preparations obtained by various procedures contain amounts of copper in the range of the heme content of this enzyme (l-9). Various workers disagree, however, on the significance of this finding (6-10). Whereas several investigators hold the view that the copper associated with cytochrome oxidase has properties that would qualify it...

The cytochrome o complex is a bo-type ubiquinol oxidase in the aerobic respiratory chain of Escherichia coli. This complex has a close structural and functional relationship with the eukaryotic and prokaryotic aa3-type cytochrome c oxidases. The specific activity, subunit composition, and metal content of the purified cytochrome o complex are not consistent for different preparative protocols r...

Extracellular and intraneuronal accumulation of amyloid-beta aggregates has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). However, the precise mechanism of amyloid-beta neurotoxicity is not completely understood. Previous studies suggest that binding of amyloid-beta to a number of macromolecules has deleterious effects on cellular functions. Mitochondria were...

Defects in mitochondrial energy metabolism lead to severe human disorders, mainly affecting tissues especially dependent on oxidative phosphorylation, such as muscle and brain. Leigh Syndrome describes a severe encephalomyopathy in infancy, frequently caused by mutations in SURF1. SURF1, termed Shy1 in Saccharomyces cerevisiae, is a conserved assembly factor for the terminal enzyme of the respi...